NCT07728656 Endothelial Extracellular Vesicles as Biomarkers of Endothelial Activation in Pregnant Women With Hypertensive Disorders of Pregnancy
| NCT ID | NCT07728656 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Josip Juraj Strossmayer University of Osijek |
| Condition | Hypertensive Disorder of Pregnancy |
| Study Type | OBSERVATIONAL |
| Enrollment | 80 participants |
| Start Date | 2026-04-01 |
| Primary Completion | 2029-04-30 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
This is an observational study. You will not receive an experimental treatment; researchers will collect data based on your existing condition or standard treatment.
This trial targets 80 participants in total. It began in 2026-04-01 with a primary completion date of 2029-04-30.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
Hypertensive disorders of pregnancy are associated with endothelial dysfunction and increased maternal and fetal morbidity. Endothelial extracellular vesicles (EEVs) have emerged as promising biomarkers of endothelial activation; however, their relationship with blood pressure and endothelial function during pregnancy remains incompletely understood. This observational case-control study aims to compare circulating EEV concentrations between normotensive pregnant women and pregnant women with hypertensive disorders of pregnancy. The study will also investigate the associations between EEV levels, blood pressure, microvascular endothelial function assessed by laser Doppler flowmetry, and circulating biomarkers of endothelial activation. The findings may improve understanding of endothelial injury during pregnancy and support the development of non-invasive biomarkers for early detection and monitoring of hypertensive disorders of pregnancy.
Eligibility Criteria
Inclusion Criteria: * Pregnant women aged ≥18 years. * Singleton pregnancy. * Ability to provide written informed consent. * Normotensive pregnancy or diagnosis of gestational hypertension or preeclampsia according to current clinical guidelines. * Ability to comply with study procedures. Exclusion Criteria: * Chronic hypertension diagnosed before pregnancy. * Multiple pregnancy. * Pre-existing diabetes mellitus. * Chronic kidney disease. * Autoimmune disease. * Known cardiovascular disease. * Active infection or inflammatory disease. * Malignancy. * Inability or unwillingness to provide informed consent.
Contact & Investigator
Ana Stupin, MD, PhD
STUDY CHAIR
Faculty of Medicine Osijek, Josip Juraj Strossmayer of Osijek
Frequently Asked Questions
Who can join the NCT07728656 clinical trial?
This trial is open to female participants only, aged 18 Years or older, studying Hypertensive Disorder of Pregnancy. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07728656 currently recruiting?
Yes, NCT07728656 is actively recruiting participants. Contact the research team at martina.vulin@mefos.hr for enrollment information.
Where is the NCT07728656 trial being conducted?
This trial is being conducted at Osijek, Croatia.
Who is sponsoring the NCT07728656 clinical trial?
NCT07728656 is sponsored by Josip Juraj Strossmayer University of Osijek. The principal investigator is Ana Stupin, MD, PhD at Faculty of Medicine Osijek, Josip Juraj Strossmayer of Osijek. The trial plans to enroll 80 participants.