NCT07312227 A Prospective Longitudinal Observational Cohort Study of Pregnant Women Residing at High Altitude in Bolivia
| NCT ID | NCT07312227 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Massachusetts General Hospital |
| Condition | Hypertensive Disorder of Pregnancy |
| Study Type | OBSERVATIONAL |
| Enrollment | 27 participants |
| Start Date | 2026-02-11 |
| Primary Completion | 2026-12 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
This is an observational study. You will not receive an experimental treatment; researchers will collect data based on your existing condition or standard treatment.
This trial targets 27 participants in total. It began in 2026-02-11 with a primary completion date of 2026-12.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
In this study, the investigators will follow two small cohorts of pregnant women: a cohort of healthy women with uncomplicated pregnancies residing at high altitude, a control group of healthy women with uncomplicated pregnancies residing at sea level, to characterize differences in cardiopulmonary adaptation and nitric oxide (NO) pathway expression at elevations \>3,500 m throughout pregnancy and into the postpartum period. The investigators aim to investigate right-sided cardiac impairment induced by chronic hypobaric hypoxemia, its effects on fetal growth, and the potential contribution of cardiovascular nitric oxide depletion to obstetric complications.
Eligibility Criteria
Inclusion Criteria: * women delivering at participating hospitals at more than 3500 meters or women delivering at participating hospitals at sea level * signed informed consent Exclusion Criteria: * preexisting cardiopulmonary pathologies (CHD, COPD, CKD, NYHA \> III)
Contact & Investigator
Lorenzo Berra, MD
PRINCIPAL INVESTIGATOR
Massachusetts General Hospital
Frequently Asked Questions
Who can join the NCT07312227 clinical trial?
This trial is open to female participants only, aged 18 Years or older, up to 45 Years, studying Hypertensive Disorder of Pregnancy. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07312227 currently recruiting?
Yes, NCT07312227 is actively recruiting participants. Contact the research team at lberra@mgh.harvard.edu for enrollment information.
Where is the NCT07312227 trial being conducted?
This trial is being conducted at Boston, United States, La Paz, Bolivia.
Who is sponsoring the NCT07312227 clinical trial?
NCT07312227 is sponsored by Massachusetts General Hospital. The principal investigator is Lorenzo Berra, MD at Massachusetts General Hospital. The trial plans to enroll 27 participants.