Emergency Stroke Unit for Acute Cerebrovascular Events ( ESU-ACE-B )
Trial Parameters
Brief Summary
To compare the door-to-puncture time of patients with hyperacute ischemic stroke (between 4.5-6 hours after the onset of symptoms) treated in a standard stroke unit adherent to guidelines versus treated in Emergency Stroke Unit (a new stroke unit based on low-field magnetic resonance imaging).
Eligibility Criteria
Inclusion Criteria: 1. Age ≥ 18 years; 2. Can be treated between 4.5-6 hours of symptoms onset\*(\*Symptom onset is defined by the "last seen normal" principle); 3. Presenting with ischemic stroke symptoms; 4. Pre-stroke mRS score 0-1; 5. Baseline NIHSS score ≥ 5; 6. Eligible for endovascular thrombectomy; 7. Informed consent signed. Exclusion Criteria: 1. Baseline NIHSS score \< 5; 2. Unable to undergo MRI because of claustrophobia; 3. Patients with cardiac pacemaker/brain pacemaker/insulin pump implantation; 4. Definite contraindication for endovascular thrombectomy; 5. Patients with postictal hemiparesis (Todd's paralysis) or those with concomitant neurological/psychiatric conditions who are unable or unwilling to cooperate; 6. Pregnant women, nursing mothers, or reluctance to use effective contraceptive measures during the period of trial; 7. Participation in other interventional randomized clinical trials within 3 months before enrollment; 8. Patients deemed unsuitable for partici