NCT07173088 Efficacy and Clinical Feasibility of the Ankle Muscle Power (AMP) Program for Return to Duty After an Ankle Fracture
| NCT ID | NCT07173088 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Brian W. Noehren |
| Condition | Ankle Fractures |
| Study Type | INTERVENTIONAL |
| Enrollment | 60 participants |
| Start Date | 2025-11-13 |
| Primary Completion | 2028-03 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 60 participants in total. It began in 2025-11-13 with a primary completion date of 2028-03.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
The goal of this clinical trial is to compare two different standardized physical therapy rehabilitation programs on outcomes after an ankle fracture. Researchers will evaluate to see if the addition of ankle muscle power exercises (AMP) improve program adherence, muscle function, physical performance, and patient reported outcomes. The main questions it aims to answer are: 1. Assess feasibility and define the initial effects of the AMP program on ankle plantar flexor rate of torque development and ankle power. Primary hypothesis: an ankle muscle power program will have acceptable feasibility through assessment of 80% adherence, 90% treatment fidelity, recruitment (48 participants who complete the study), 80% retention, and 80% acceptability of the AMP program to facilitate clinical translation and the ability to scale-up the treatment. In addition ankle plantar flexor muscle power, plantar flexor RTD assessed isometrically, and ankle joint power, evaluated during gait and stair ascent/descent, will have significantly greater improvements in the AMP group than the standard of care group at the end of the intervention. 2. Test the effect of the AMP program on physical performance. Primary hypothesis: those completing the AMP program will have greater improvements in the 40 meter fast paced walk test and 11-stair climb test than those completing standard of care at the completion of the intervention. 3. Assess the preliminary efficacy of the AMP program on patient reported outcomes and quality of life. Primary hypothesis: compared to standard of care, the AMP program will result in improved quality of life on the ankle fracture outcome rehabilitation measure (A-FORM) Participants will complete rehabilitation and be assessed for outcomes at baseline and after completing the intervention. Additionally exploratory outcomes will be assessed 3 months after completing the intervention.
Eligibility Criteria
Inclusion Criteria: * Age 18-50 years old * Acute orthopedic injury to the ankle requiring surgical fixation * Must have stable address and phone number to schedule follow up contact visits * English speaking * BMI ≤ 35 kg/m2 Exclusion Criteria: * History of chronic pain defined as pain lasting more than 3 months and bothersome at least half the days over the past 6 months that started before the fracture * Moderate or severe traumatic brain injury * Initial treatment requiring amputation * Spinal cord injury * Unable to speak or read English * History of schizophrenia, dementia, neurologic disorder with peripheral dysfunction, or other psychotic disorder based upon medical record or patient self-report * Any chronic conditions that would limit their ability to participate in an intervention * Multiple trauma that prevents engaging in intervention * Pregnant * Unable to participate in or complete in-person follow up visits or therapy sessions * In Physical Therapy at the start of the intervention. * Use of an assistive device to walk for community ambulation * Prior lower extremity fracture within the past 2 years
Contact & Investigator
Principal Investigator
PRINCIPAL INVESTIGATOR
University of Kentucky
Frequently Asked Questions
Who can join the NCT07173088 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, up to 50 Years, studying Ankle Fractures. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07173088 currently recruiting?
Yes, NCT07173088 is actively recruiting participants. Contact the research team at delong2@uky.edu for enrollment information.
Where is the NCT07173088 trial being conducted?
This trial is being conducted at Lexington, United States.
Who is sponsoring the NCT07173088 clinical trial?
NCT07173088 is sponsored by Brian W. Noehren. The principal investigator is Principal Investigator at University of Kentucky. The trial plans to enroll 60 participants.