Effects of COPD Standardized Management on COPD Exacerbation
Trial Parameters
Brief Summary
This is a multi-center, parallel-group,cluster randomised trial involving secondary hospitals across China. The objective is to evaluate the effect of COPD on reducing moderate-to-severe exacerbations during 12 months follow-up in primary-level medical institutions.
Eligibility Criteria
Inclusion Criteria: 1. Aged ≥40 years 2. Post-bronchodilator FEV1/FVC \<70% 3. Baseline CAT score ≥10 or history of exacerbation in previous 12 months, defined as any use of oral antibiotics and/or oral or nebulized corticosteroids for increased cough, sputum and dyspnea, or exacerbation requiring hospitalization/ emergency admission. 4. Local residents who live nearby and can be followed up throughout study period 5. Written informed consent Exclusion Criteria: 1. Pregnancy, breastfeeding, or potential pregnancy 2. Primary diagnosis of asthma 3. Having severe cognitive dysfunction 4. Severely ill with less than 12-month life expectancy 5. Patients with alcohol abuse history are excluded as alcoholic individuals may have low adherence to the study. Alcohol abuse is defined as an average alcohol intake \>80 g per day within recent two weeks, or daily intake of ≥40 g alcohol in men, and ≥20 g alcohol in women for more than 5 years. 6. Have participated in similar trials or are undergoing