NCT06791915 Effect of Mechanical Ventilation on Radiofrequency Ablation in Atrial Fibrillation
| NCT ID | NCT06791915 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Kocaeli City Hospital |
| Condition | Radiofrequency Ablation |
| Study Type | OBSERVATIONAL |
| Enrollment | 50 participants |
| Start Date | 2025-01-01 |
| Primary Completion | 2025-07-01 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
This is an observational study. You will not receive an experimental treatment; researchers will collect data based on your existing condition or standard treatment.
This trial targets 50 participants in total. It began in 2025-01-01 with a primary completion date of 2025-07-01.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
Radiofrequency ablation (RFA) for atrial fibrillation (AF) is performed under general anesthesia. The success of the procedure depends on the safe contact of the catheter electrode with the myocardium. Movement of the catheter tip due to respiratory changes can result in inadequate lesion formation and AF recurrence. The success of AF ablation depends on the adequacy of energy delivered to the myocardium and the durability of pulmonary vein isolation (PVI). Poor energy delivery and tissue heating during ablation are a major cause of procedural failure in RFA. To improve the success of the PVI procedure, efforts are underway to optimize catheter stability and contact force. However, catheter force and stability are influenced by respiration-induced thoracic motion, highlighting the importance of controlled breathing for further optimization. Fluoroscopy and ablation times during electroanatomic mapping-guided AF ablations improved with controlled mechanical ventilation. General anesthesia improved catheter contact. Low tidal volume, high respiratory rate (FCV), pressure controlled mechanical ventilation (PCV), volume controlled mechanical ventilation (VCV), pressure controlled volume assured mechanical ventilation (PRVC) can be used in investigators' hospital. The literature offers no definitive proof that one ablation procedure is superior to another.
Eligibility Criteria
Inclusion Criteria: * Diagnosed with atrial fibrillation * planned to receive radiofrequency ablation treatment under general anesthesia * all patients over 18 years of age Exclusion Criteria: \- Patients undergoing ablation under sedation and/or local anesthesia
Contact & Investigator
Frequently Asked Questions
Who can join the NCT06791915 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, studying Radiofrequency Ablation. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT06791915 currently recruiting?
Yes, NCT06791915 is actively recruiting participants. Contact the research team at merreset@hotmail.com for enrollment information.
Where is the NCT06791915 trial being conducted?
This trial is being conducted at Kocaeli, Turkey (Türkiye).
Who is sponsoring the NCT06791915 clinical trial?
NCT06791915 is sponsored by Kocaeli City Hospital. The trial plans to enroll 50 participants.