NCT06937853 Effect of Genetic Polymorphisms on Response to Preoperative NSAIDs in Endodontic Postoperative Pain Management
| NCT ID | NCT06937853 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Ataturk University |
| Condition | Postoperative Pain |
| Study Type | INTERVENTIONAL |
| Enrollment | 200 participants |
| Start Date | 2024-05-10 |
| Primary Completion | 2025-07-10 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 200 participants in total. It began in 2024-05-10 with a primary completion date of 2025-07-10.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
This study aims to evaluate the influence of genetic polymorphisms on the effectiveness of preoperative non-steroidal anti-inflammatory drugs (NSAIDs) in managing postoperative pain following endodontic treatment. Participants will receive standard preoperative NSAIDs before undergoing root canal therapy, and their pain responses will be assessed. Genetic analysis will be performed to investigate possible associations between drug response and individual gene variations. The study seeks to improve personalized approaches in endodontic pain management.
Eligibility Criteria
Inclusion Criteria: 1. Patients aged between 18 and 65 years 2. Vital mandibular molar teeth diagnosed with symptomatic apical periodontitis 3. ASA physical status classification I or II 4. Preoperative VAS pain score greater than 50 5. No known genetic disorders (e.g., Down syndrome, congenital insensitivity to pain) Exclusion Criteria: 1. Patients classified as ASA III or higher 2. Pregnant women or those suspected of being pregnant 3. Presence of root canal curvature greater than 25° (Schilder classification) 4. Patients with generalized periodontitis 5. Presence of periodontal pockets deeper than 3 mm in the affected tooth 6. History of systemic disease or known allergies 7. Patients with diagnosed psychiatric or psychological disorders 8. Presence of swelling, sinus tract, or preoperative tenderness on palpation 9. Patients with bruxism 10. Presence of resorption in the affected tooth 11. Use of analgesic or anti-inflammatory drugs within 12 hours prior to the procedure 12. Teeth with root fractures, ankylosis, or pathological mobility
Contact & Investigator
Ertugrul Karatas, Prof. Dr.
PRINCIPAL INVESTIGATOR
Ataturk University, Faculty of Dentistry, Department of Endodontics
Frequently Asked Questions
Who can join the NCT06937853 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, up to 65 Years, studying Postoperative Pain. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT06937853 currently recruiting?
Yes, NCT06937853 is actively recruiting participants. Contact the research team at dtertu@windowslive.com for enrollment information.
Where is the NCT06937853 trial being conducted?
This trial is being conducted at Erzurum, Turkey (Türkiye).
Who is sponsoring the NCT06937853 clinical trial?
NCT06937853 is sponsored by Ataturk University. The principal investigator is Ertugrul Karatas, Prof. Dr. at Ataturk University, Faculty of Dentistry, Department of Endodontics. The trial plans to enroll 200 participants.