Effect of Alternate Day Fasting Over Standard Medical Management Alone to Reverse Non-alcoholic Steatohepatitis.
Trial Parameters
Brief Summary
The aims of this study are as follows: To compare the role of alternate-day fasting over standard medical management alone to reverse NASH.
Eligibility Criteria
Inclusion Criteria: * Age 18-65 years. BMI 25-40kg/m3, and CAP more than 290 * Stable weight in the last 3 months prior to enrolling in the study(\<5kg weight variation) * Imaging showed steatotic liver disease, liver stiffness \<14kPa measured by fibroscan * Histologically proven NASH/MASH, fibrosis up to F3 * Subjects willing to participate in the study Exclusion Criter * Liver stiffness \>14kPa measured by fibroscan or Fibrosis \>F3 * Diabetes with HbA1c\>8.5% * Patients with another co-existing active liver disease e.g. hepatitis B or C, alcoholic liver disease * Patients with cirrhosis, hepatocellular carcinoma(HCC), or other malignancy * Chronic kidney disease, cardiovascular disorders, uncontrolled hypertension * Chronic infections, chronic inflammatory diseases * Patients on weight loss medications e.g semaglutide * Pregnant or lactating women and those planning a pregnancy A patient who is not willing to participate in the study or failed to provide the consent