Dose-Dependent Effects of Low-Intensity Focused Ultrasound
Trial Parameters
Brief Summary
Low-intensity focused ultrasound (LIFU) has emerged as a tool to modulate the activity of deep brain structures noninvasively and reversibly, with anatomical precision. Following the results of a pilot study in which the investigators observed target engagement when LIFU was applied to the anterior limb of the internal capsule, the investigators now propose to determine the dose-response relationships of LIFU when applied to deep white matter tracts of the human brain. The investigators hope a successful study will be rapidly translatable into clinical trials seeking to understand mechanistic brain circuit-symptom relationships in major psychiatric disorders.
Eligibility Criteria
Inclusion Criteria: * Age 18 to 65 years. * Body mass index 17-38 kg/m2. * Fluent English speaker, capable of providing written informed consent. * Overall Anxiety Severity and Impairment Scale \<8 and Patient Health Questionnaire-9 \<10 * A person of childbearing potential must have a negative urine pregnancy test at screening * Consent that random observations of pathology are possible (e.g., brain abnormality seen during imaging). Exclusion Criteria: * Inability to provide informed consent including medical, psychiatric, or other conditions that restrict the patient's following abilities: to interpret the study information, to give informed consent, to adhere to the rules of the protocol, or complete the study. * No telephone or easy access to telephone * Has active suicidal ideation (as measured by Suicide-Risk-Assessment-C-SSRS "Yes" answers to items 3, 4, or 5 Suicidal Ideation-Past 1 month section, or any "Yes" answer to any of the items of Suicidal Behavior-Past 3 months sectio