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Recruiting NCT05903001

NCT05903001 Diaphragmatic Function as a Biomarker

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Clinical Trial Summary
NCT ID NCT05903001
Status Recruiting
Phase
Sponsor RWTH Aachen University
Condition Dyspnea; Asthmatic
Study Type OBSERVATIONAL
Enrollment 800 participants
Start Date 2023-07-01
Primary Completion 2026-12-30

Eligibility & Interventions

Sex All sexes
Min Age 18 Years
Max Age N/A
Study Type OBSERVATIONAL
Interventions
Diaphragm UltrasoundIntercostal Muscle UltrasoundBorg scale

Eligibility Fast-Check

Enter your details for a quick preliminary check. This does not replace medical advice.

What to Expect as a Participant

This is an observational study. You will not receive an experimental treatment; researchers will collect data based on your existing condition or standard treatment.

This trial targets 800 participants in total. It began in 2023-07-01 with a primary completion date of 2026-12-30.

⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.

Brief Summary

Dyspnea is among the most common symptoms in patients with respiratory diseases such as Asthma, chronic obstructive pulmonary disease (COPD), Fibrosis, and Pulmonary Hypertension. However, the pathophysiology and underlying mechanisms of dyspnea in patients with respiratory diseases are still poorly understood. Diaphragm dysfunction might be highly prevalent in patients with dyspnea and respiratory diseases. The association of diaphragm function and potential prognostic significance in patients with respiratory diseases has not yet been investigated.

Eligibility Criteria

Inclusion Criteria: * patient has one of the following lung diseases: COPD, bronchial asthma, pulmonary fibrosis, pulmonary hypertension * is 18 years or older * is mentally and physically able to understand the study and to follow instructions * are legally competent * signed declaration of consent Exclusion Criteria: * BMI \> 35 * current or treatments or diseases in the past which could influence the evaluation of the study * Expected lack of willingness to actively participate in study-related measures * alcohol or drug abuse * disc herniation/prolapse * epilepsy * wheelchair bound * in custody due to an official or court order * in a dependent relationship or employment relationship with investigating physician or one of their deputy * emergency inpatient hospital stay within 4 weeks before study-specific examinations

Contact & Investigator

Central Contact

Jens Spiesshoefer, MD

✉ jspiesshoefer@ukaachen.de

📞 0049 2418037036

Principal Investigator

Michael Dreher, MD

STUDY DIRECTOR

Uniklinik RWTH Aachen

Frequently Asked Questions

Who can join the NCT05903001 clinical trial?

This trial is open to participants of all sexes, aged 18 Years or older, studying Dyspnea; Asthmatic. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.

Is NCT05903001 currently recruiting?

Yes, NCT05903001 is actively recruiting participants. Contact the research team at jspiesshoefer@ukaachen.de for enrollment information.

Where is the NCT05903001 trial being conducted?

This trial is being conducted at Aachen, Germany.

Who is sponsoring the NCT05903001 clinical trial?

NCT05903001 is sponsored by RWTH Aachen University. The principal investigator is Michael Dreher, MD at Uniklinik RWTH Aachen. The trial plans to enroll 800 participants.

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ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer  ·  Last Reviewed: April 2026  ·  Data Methodology