NCT07406867 Diagnostic Accuracy of Oral Images, OPGs, Biomarkers and Questionnaires vs. Clinical Assessment for Periodontal Disease (PostNCT07164573)
| NCT ID | NCT07406867 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University |
| Condition | Periodontal Disease |
| Study Type | OBSERVATIONAL |
| Enrollment | 2,000 participants |
| Start Date | 2026-03-01 |
| Primary Completion | 2029-03-01 |
Eligibility & Interventions
Eligibility Fast-Check
Enter your details for a quick preliminary check. This does not replace medical advice.
What to Expect as a Participant
This is an observational study. You will not receive an experimental treatment; researchers will collect data based on your existing condition or standard treatment.
This trial targets 2,000 participants in total. It began in 2026-03-01 with a primary completion date of 2029-03-01.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
This multi-center, cross-sectional diagnostic trial evaluates the accuracy of multiple non-invasive screening tools-including self-reported questionnaires, intra-oral photographs, orthopantomographs (OPGs), intraoral scans (IOS), and salivary/microbial biomarkers-for detecting periodontal health and diseases (gingivitis and periodontitis Stages I-IV), using full-mouth clinical periodontal examination as the reference standard. A total of 2,000 participants will be recruited across five international centers. Diagnostic performance (sensitivity, specificity, AUROC) of individual and combined methods will be assessed using logistic regression and machine learning algorithms to establish an optimized multi-modal screening algorithm.
Eligibility Criteria
Inclusion Criteria: * Adult patients aged 18 years or older. * Seeking dental care at one of the participating study centers. * Ability to understand and willingness to provide written informed consent. Exclusion Criteria: * Edentulous patients (complete tooth loss). * Pregnancy or lactation. * History of periodontal therapy (other than supragingival prophylaxis/cleaning) within the past 12 months. * Use of antibiotic medication within the 3 months prior to enrollment.
Contact & Investigator
Frequently Asked Questions
Who can join the NCT07406867 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, studying Periodontal Disease. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07406867 currently recruiting?
Yes, NCT07406867 is actively recruiting participants. Contact the research team at tonetti@hku.hk for enrollment information.
Where is the NCT07406867 trial being conducted?
This trial is being conducted at Shanghai, China, Roma, Italy, London, United Kingdom.
Who is sponsoring the NCT07406867 clinical trial?
NCT07406867 is sponsored by Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University. The trial plans to enroll 2,000 participants.