NCT07388342 Diagnostic Accuracy of ECG-less Gated Cardiac CT in Resuscitated Cardiac Arrest Survivors Without ST Elevation Myocardial Infarction
| NCT ID | NCT07388342 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Universitair Ziekenhuis Brussel |
| Condition | Cardiac Arrest (CA) |
| Study Type | INTERVENTIONAL |
| Enrollment | 30 participants |
| Start Date | 2025-09-01 |
| Primary Completion | 2027-09-01 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 30 participants in total. It began in 2025-09-01 with a primary completion date of 2027-09-01.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
In a significant portion of patients surviving a cardiac arrest, the event is caused by a myocardial infarction (a narrowing or blockage of one or more blood vessels that supply blood to the heart, the coronary arteries). In some people, this is immediately evident from basic tests; in others, it is more difficult to predict with the currently available tests whether this (or something else) caused the cardiac arrest. We investigate a technique that allows us to also assess the coronary arteries on the CT scan that is performed in patients surviving a cardiac arrest. The coronary angiography is currently the best exam we have for examining the coronary arteries, but it has some disadvantages. Compared to the CT scan, it takes more time, needs a more complex access to the blood vessels, and has some rare but relevant possible complications. The major advantage of the coronary angiography is that there is the possibility of immediate treatment of a narrowed/blocked blood vessel of the heart. The current guidelines advice an urgent coronary angiography when a clear myocardial infarction is suggested on the electrocardiogram, but not when there is no clear indication of myocardial infarction. Nonetheless, a relevant portion (more or less 40%) of the patients without a clearly abnormal electrocardiogram, still have an important problem in the blood vessels of the heart. We aim to determine whether the CT scan provides accurate information about the condition of the blood vessels of the heart. The CT scan was already well examined for this purpose before, but in the currently conventional way it needs preparation with extra monitoring and administration of medication, which would lead to loss of precious time and potentially dangerous side effects of these drugs in this critical situation. For that reason, a new software modality was developed that allows us to examine the coronary arteries in the same CT scan, without need for additional monitoring or medication administration. It does not need additional contrast administration (the dye necessary for optimal evaluation of some diseases). The goal of this study is to determine whether this new technique gives us the correct information about the coronary arteries. This means we acquire the images of the heart in the same scan, and verify the results with the conventional coronary angiography. If the technique provides accurate information, it could lead to a better selection of patients we need to urgently refer for a coronary angiography and to defer the exam in those who have normal coronary arteries on the scan.
Eligibility Criteria
* Inclusion: * Adults (≥18 years) with sustained return of spontaneous circulation (ROSC) following in/out-of-hospital cardiac arrest. * Informed consent from patient or representative obtained before invasive coronary angiography. * Exclusion * Patients on VA-ECMO * ACS STEMI or STEMI "equivalent" * New left/right bundle branch block * ST segment depression in leads V1-V3, when the terminal T wave is positive and concomitant ST-segment elevation ≥ 0,5mm recorded in leads V7-V9 (posterior MI) * ST-segment elevation in V7-V9 (posterior MI) or V3R-V4R (RV MI) * ACS NSTEMI with persistent ST depression despite optimal therapy, suggesting ongoing myocardial ischemia, with indication for an urgent ICA according to the treating physician. * Hemodynamic/electrical instability precluding CT imaging (as perceived by the treating physician) * Life-threatening arrhythmia potentially caused by acute myocardial ischemia * Absolute contraindications to iodinated contrast * Patients with a known non-cardiac cause of cardiac arrest (e.g., traumatic brain injury, overt hemorrhage, asphyxia/severe hypoxia due to known lung disease, trauma, severe metabolic/electrolyte derangement, or intoxication) as perceived by the treating physician, where chest CT is considered unnecessary. * Known or likely pregnancy or lactation * Severe bleeding issue (as perceived by the treating physician) precluding heparin administration during radial access coronary angiography. * Prior coronary intervention (stent implantation/CABG). * CT findings indicating a condition that precludes coronary angiography in the short term. * Patients with end-of-life care pathways. * Participation in another intervention study interfering with the research questions in OPEN CCT Arrest.
Frequently Asked Questions
Who can join the NCT07388342 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, studying Cardiac Arrest (CA). Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07388342 currently recruiting?
Yes, NCT07388342 is actively recruiting participants. Visit ClinicalTrials.gov or contact Universitair Ziekenhuis Brussel to inquire about joining.
Where is the NCT07388342 trial being conducted?
This trial is being conducted at Brussels, Belgium.
Who is sponsoring the NCT07388342 clinical trial?
NCT07388342 is sponsored by Universitair Ziekenhuis Brussel. The trial plans to enroll 30 participants.