NCT05197920 Diabetes RElated to Acute Pancreatitis and Its Mechanisms
| NCT ID | NCT05197920 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Milton S. Hershey Medical Center |
| Condition | Acute Pancreatitis |
| Study Type | OBSERVATIONAL |
| Enrollment | 800 participants |
| Start Date | 2022-01-14 |
| Primary Completion | 2030-01-31 |
Trial Parameters
Eligibility Fast-Check
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Brief Summary
The overriding objective of DREAM is to conduct a prospective longitudinal (36 months) observational clinical study to investigate the incidence, etiology, and pathophysiology of diabetes mellitus (DM) following acute pancreatitis (AP).
Eligibility Criteria
Inclusion Criteria: * Diagnosis of acute pancreatitis (AP) 0-90 days prior to enrollment date * Participant fully understands and is able to participate in all aspects of the study, including providing informed consent, completion of case report forms (CRFs), telephone interviews, metabolic testing, and planned longitudinal follow-ups Exclusion Criteria: * Diagnosis of definite chronic pancreatitis (CP) at enrollment based on either of the following criteria met by computed tomography (CT) scan (including non-contrast enhanced) or Magnetic resonance Imaging (MRI) or Magnetic Resonance Cholangiopancreatography (MRCP): (a) Parenchymal or ductal calcifications on CT scan (after excluding the possibility that calcifications are vascular); (b) Intraductal filling defects suggestive of calcifications on MRI and/or MRCP * Potential participants with post-endoscopic retrograde cholangiopancreatography (post- ERCP) AP who are hospitalized for \<48 hours. * Prior (i.e., before enrollment) direct