Deep Brain Stimulation for Visuomotor Function in Parkinson's Disease
Trial Parameters
Brief Summary
Inability to align and refocus the eyes on the objects at different depths, i.e., vergence impairment, frequently affects the quality of life in patients with Parkinson's disease. Our study aims to understand the location-specific effects of subthalamic region deep brain stimulation on vergence by integrating the patient-specific deep brain stimulation models and high-resolution eye-tracking measures. The knowledge gained will allow us to find the most beneficial stimulation location and parameters for improving binocular coordination and vergence while preserving the ability to treat motor symptoms in Parkinson's disease.
Eligibility Criteria
Inclusion Criteria: * Parkinson's disease with bilateral STN DBS * Availability of pre-operative MR images (with a T1-weighted, gradient-echo sequence) and ability to get post-operative MRI or CT scans * Hoehn and Yahr stage 2-4 when off medication, and a stable antiparkinsonian medication regimen and DBS parameter settings Exclusion Criteria: * Previous surgical therapy for Parkinson's disease (other than DBS) * Dementia * Clinically significant untreated depression or anxiety * Clinical features suggestive of atypical parkinsonism