Trial Parameters
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Brief Summary
The goal of this clinical trial is to examine the neural mechanisms underlying transcranial magnetic stimulation (TMS) using concurrent functional magnetic resonance imaging (fMRI) in both healthy controls (HCs) and patients with high negative affect symptoms, such as depression. Approximately half male and half female participants aged 18-65 will be recruited. The main questions it aims to answer are: 1. Is the acute/transient effect induced by single-pulse TMS related to the long-term modulatory effect induced by repetitive TMS (rTMS)? 2. Do any of these effects predict negative affect symptoms, such as depression? Participants will: 1. Complete several tests to assess their cognitive abilities and emotional states 2. Undergo several brain scans, including resting-state fMRI, structural MRI, diffusion tensor imaging (DTI), and task fMRI 3. Have two different types of TMS sequences, single-pulse and repetitive pulses, administered to specific brain regions while undergoing fMRI
Eligibility Criteria
Inclusion for patients: * Diagnosis of major depressive disorder * Age greater than or equal to 18 years * Age less than or equal to 65 years * Able to understand and consent for research participation * English-speaking Inclusion for healthy controls: * Report no lifetime psychiatric diagnosis and treatment * scores on Patient Health Questionnaire (PHQ-9) and Generalized Anxiety Disorder Questionnaire (GAD-7) lower than 4 * Age greater than or equal to 18 years * Age less than or equal to 65 years * Able to understand and consent for research participation * English-speaking Exclusion for all subjects: * Age less than 18 years * Age greater than 65 years * With epilepsy or seizure disorder * With implanted ferromagnetic equipment in their face or skull near the stimulation target MRI Exclusion criteria for all subjects: * Implanted device including pacemaker, coronary stent, defibrillator, or neurostimulation device that is not MRI-compatible * Metal in body including bullets, shrapne