NCT07248709 Comparison of High-Intensity Interval Training and Moderate-Intensity Continuous Training in Mild Cognitive Impairment
| NCT ID | NCT07248709 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Riphah International University |
| Condition | Mild Cognitive Impairment |
| Study Type | INTERVENTIONAL |
| Enrollment | 68 participants |
| Start Date | 2025-11-05 |
| Primary Completion | 2026-04-12 |
Trial Parameters
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Brief Summary
This study aims to determine the effects of High-Intensity Interval Training (HIIT) and Moderate-Intensity Continuous Training (MICT) on cognitive and physical fitness in community-dwelling adults diagnosed with Mild Cognitive Impairment (MCI). A double-blinded randomized clinical trial will be conducted for ten months at Ruhama Welfare Foundation Society Lahore and Kainat Patient Care and Old Age Home, Lahore. The sample size is calculated through G-power and 68 participants will be recruited through the non-probability convenience sampling technique. Those who meet the inclusion criteria will be randomized into two groups through the online randomizer tool. Both experimental groups will undergo an 8-week intervention, consisting of three sessions per week with alternate-day training of 38 minutes. The HIIT group will perform exercise with each session consisting of four 4-minute intervals at 85-95% of their maximum heart rate, with 3-minute active recovery periods, while the MICT group will engage in continuous exercise for 28 minutes at 70-75% of their maximum heart rate. Assessment will be done at baseline, after the 4th week, 8th week, and follow-up at 12th week.
Eligibility Criteria
Inclusion Criteria: * older adults who had been diagnosed with MCI according to Peterson's criteria \[Montreal Cognitive Assessment (MoCA) score \<26 for those with 12 years or more of education and \<25 for those with less than 12 years of education; activity of daily living scale ≤23; no clinical diagnosis of dementia\] * older adults who are physically normal (the six-item Katz Activities of Daily Living Scale should all be evaluated as "independent") Exclusion Criteria: * Participants who have medical problems or co-morbidities that interdict their participation in the study. * Unable to walk without an assistive device * Diagnosed with neurodegenerative diseases such as Alzheimer's disease * Having regular exercise habits (defined as exercise for ≥150 min per week). * Participating in other ongoing intervention study