Comparing Efficiency of Mirogabalin and Pregabalin in Primary TKA
Trial Parameters
Brief Summary
The goal of this RCT is to compare efficacy between mirogabalin and pregabalin in pain reducing after unilateral primary total knee arthroplasty. The main question\[s\] it aims to answer are: • Does mirogabalin have better pain reduction than pregabalin after unilateral primary total knee arthroplasty. Participants will randomized to mirogabalin or pregabalin group and will take the drug for 6 weeks after TKA. Researchers will compare to pregabalin group to see pain and functional outcomes after TKA.
Eligibility Criteria
Inclusion Criteria: 1. Age 50-85 years old 2. Unilateral primary osteoarthritis undergoing primary TKA 3. ASA I-III Exclusion Criteria: 1. GFR \<60 2. Allergy to drug in this study 3. Cannot underwent spinal anesthesia and adductor canal block 4. Taking gabapentinoid within 3 months before surgery 5. History of previous knee surgery 6. Severe liver disease