NCT05041478 Cold Snare Endoscopic Mucosal Resection (EMR) vs Cold EMR With Margin Snare Tip Soft Coagulation (STSC)
| NCT ID | NCT05041478 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Western Sydney Local Health District |
| Condition | Colorectal Polyp |
| Study Type | INTERVENTIONAL |
| Enrollment | 300 participants |
| Start Date | 2023-09-19 |
| Primary Completion | 2028-10-01 |
Trial Parameters
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Brief Summary
Randomised controlled trial comparing cold snare endoscopic mucosal resection (EMR) with cold snare EMR and adjuvant margin STSC in the complete resection of 15-40mm lateral-spreading adenomas
Eligibility Criteria
Inclusion Criteria: * Any patient undergoing colonoscopy who is older than 18 years of age, has a written consent for trial participation and has at least one laterally spreading lesion meeting the following description: * Localisation in the colon or rectum * Benign adenomatous surface features (Kudo III / IV, Japan NBI Expert Team (JNET) 2a) * Granular or non-granular topography * Paris classification 0-IIa/IIb +/- Is * If present, sessile component may be no greater than 10mm in size. * Polyp size ranging from 15 to 40mm Exclusion Criteria: * Current use of antiplatelet (excluding aspirin) or anticoagulants which have not appropriately been interrupted according to the guidelines. * Known bleeding disorder or coagulopathy. * Pregnancy * History of inflammatory bowel disease * Previously attempted or otherwise non-lifting lesions * Endoscopic features suggestive of submucosal invasion (Kudo Vi/n, JNET 2b / 3) or concurrent colorectal cancer * Lesions involving the ileocaecal valve (I