NCT07316543 Cognitive Rehabilitation for Veterans With PNES
| NCT ID | NCT07316543 |
| Status | Recruiting |
| Phase | — |
| Sponsor | VA Office of Research and Development |
| Condition | Psychogenic Nonepileptic Seizures (PNES) |
| Study Type | INTERVENTIONAL |
| Enrollment | 47 participants |
| Start Date | 2026-03-02 |
| Primary Completion | 2031-07-01 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 47 participants in total. It began in 2026-03-02 with a primary completion date of 2031-07-01.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
Psychogenic nonepileptic seizures (PNES) reflect a subtype of functional neurological disorder (FND) that is common and extremely disabling in Veterans. Cognitive problems are highly prevalent in PNES, they reduce quality of life, and they severely limit daily functioning. Currently, there are no available treatments that target cognition to improve daily function in PNES or other FNDs, leaving a major gap in the literature. Cognitive re-habilitation improves daily functioning in Veterans with related neuropsychiatric disorders and has a high chance of success in Veterans with PNES. The proposed study will solicit direct input from Veterans with PNES via qualitative interviews to inform the design of a cognitive treatment workbook. The workbook will then be iteratively refined based on participatory feedback from Veterans with PNES and their treatment providers. The full cognitive intervention protocol will be pilot tested to inform a fully powered RCT. Results will support a line of research that aims to improve cognition and function in Veterans with PNES and related FNDs.
Eligibility Criteria
Inclusion Criteria: * U.S. Veteran * able to provide informed consent * reports cognitive difficulties * prior video EEG diagnosis of PNES * English speaking * able to read at least at 8th grade level * access to a private space with a computer (13-inch monitor) * internet access Exclusion Criteria: * acute psychosis (hallucinations or delusions) * current active suicidality * a diagnosis of dementia or intellectual disability * sensory impairment (e.g., deafness) that would preclude participation
Contact & Investigator
Ryan A Van Patten, PhD
PRINCIPAL INVESTIGATOR
Providence VA Medical Center, Providence, RI
Frequently Asked Questions
Who can join the NCT07316543 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, studying Psychogenic Nonepileptic Seizures (PNES). Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07316543 currently recruiting?
Yes, NCT07316543 is actively recruiting participants. Contact the research team at Madeleine.Lefkowitz@va.gov for enrollment information.
Where is the NCT07316543 trial being conducted?
This trial is being conducted at Providence, United States.
Who is sponsoring the NCT07316543 clinical trial?
NCT07316543 is sponsored by VA Office of Research and Development. The principal investigator is Ryan A Van Patten, PhD at Providence VA Medical Center, Providence, RI. The trial plans to enroll 47 participants.