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Recruiting NCT06772831

Cognitive Reappraisal Training for Borderline Personality (BPD)

Trial Parameters

Condition Borderline Personality Disorder
Sponsor Icahn School of Medicine at Mount Sinai
Study Type INTERVENTIONAL
Phase N/A
Enrollment 130
Sex ALL
Min Age 18 Years
Max Age 55 Years
Start Date 2024-11-15
Completion 2027-07-31
Interventions
Cognitive Reappraisal by DistancingDownregulate condition

Brief Summary

Previous work by the group convinced the researchers to pursue development of focused cognitive reappraisal training as a novel approach to treatment of BPD, either as stand-alone treatment or in concert with evidence-based treatments of BPD. The present proposal aims to refine and test a proposed clinical intervention for BPD patients, training in reappraisal-by-distancing, in terms of its ability to influence hypothesized neural and behavioral targets and, once that is established, to demonstrate its ability improve clinically relevant outcome measures.

Eligibility Criteria

Inclusion Criteria: * Medically healthy men and women with Borderline Personality Disorder who are mentally competent and give informed voluntary written consent. * Participants will be between the ages of 18 and 55. * Within these requirements, the inclusion and exclusion criteria do not reflect participation based on gender or racial/ethnic group. The targeted/planned enrollment is a reflection of previous recruitment of female and ethnic minorities in other studies conducted by the PI and their colleagues and includes representations of both genders and all minorities. * Participants with comorbid avoidant personality disorder will be included. * Participants who meet criteria for PTSD will be included as long as they are not actively experiencing symptoms. Exclusion Criteria: * Participants will not meet criteria for Schizotypal Personality Disorder. * Participants currently meeting criteria for Major Depressive Disorder will be excluded. * BPD participants will not meet DSM-5 crit

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