NCT06514313 Clinical Trial of VIM With VIT in Children With Relapsed and Refractory Soft Tissue Sarcoma.
| NCT ID | NCT06514313 |
| Status | Recruiting |
| Phase | Phase 2 |
| Sponsor | Yizhuo Zhang |
| Condition | Soft Tissue Sarcoma |
| Study Type | INTERVENTIONAL |
| Enrollment | 110 participants |
| Start Date | 2024-07-03 |
| Primary Completion | 2026-08-01 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
In Phase 2, researchers evaluate early signs of effectiveness. You may be randomized to receive the active treatment or a comparator. Monitoring continues closely.
This trial targets 110 participants in total. It began in 2024-07-03 with a primary completion date of 2026-08-01.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
Explore the efficacy and safety of mitoxantrone liposome combined with irinotecan and vincristine (VIM) in the treatment of relapsed/refractory soft tissue sarcoma in children.
Eligibility Criteria
Inclusion Criteria: * 2 years ≤age≤21 years, no gender limitation. * The Karnofsky (≥16 years old) or Lansky (\< 16 years old) physical status score is at least 70. * The expected survival time is not less than 12 weeks. * Heart function: a) Cardiac COLOR ultrasound detection LVEF≥ 50%; b) ECG suggests no myocardial ischemia; c) No history of arrhythmia requiring drug intervention before enrollment. * Pathological results for patients of soft tissue sarcoma. * Patients with rhabdomyosarcoma are limited to first -, second -, and third-line treatment, and patients with other pathological subtypes are limited to progression, recurrence, or refractory after first-line treatment, with refractory defined as failure to achieve complete or partial response to the most recent treatment. * Measurable lesions (according to RECIST 1.1 standards, measurable lesions have not received radiotherapy, freezing and other local treatments). * The patient must fully recover from the acute toxic effects of all previous anticancer chemotherapy. * Good blood and organ function. * During study participation, patients are able to adhere to outpatient treatment, laboratory monitoring, and necessary clinical visits. * The parent/guardian of the child or adolescent subject is capable of understanding, agreeing to, and signing the study Informed consent (ICF) and the applicable child consent form prior to initiating any program-related procedures; Subject is capable of expressing consent with parental/guardian consent (if applicable). Exclusion Criteria: * Once received mitoxantrone or mitoxantrone liposomes. * Patients who had received previous VIT (irinotecan + temozolomide + vincristine) chemotherapy. * Previous treatment with adriamycin or other anthracyclines with a total cumulative dose of adriamycin \> 360 mg/m\^2; Or patients with cardiac disease caused by previous anthracyclines. * Receiving or not being able to discontinue P450 enzyme-induced anticonvulsant drugs (e.g., phenytoin, carbamazepine, etc.) within 4 weeks or 5 half-life periods prior to enrollment. * Previous or concurrent clinical significance of active cardiovascular diseases. * Severe chronic skin diseases in the past. * Previous allergic asthma or severe allergic disease. * Uncontrolled hypertension and diabetes. * Have a history of other tumors, except cured cervical cancer or basal cell carcinoma of the skin. * Active hepatitis B or hepatitis C infection. * HIV or syphilis infected patients. * Patients who have previously received organ transplants. * Uncontrolled active systemic bacterial, viral, or fungal infection. * Contraindications to high-dose hormone use, such as uncontrolled hyperglycemia, gastric ulcers, or psychiatric disorders. * Severe neurological or psychiatric history, including epilepsy or autism. * Pregnant, lactating women and patients of childbearing age who are unwilling to use contraception. * Other circumstances deemed inappropriate by the investigator to participate in the study.
Contact & Investigator
Frequently Asked Questions
Who can join the NCT06514313 clinical trial?
This trial is open to participants of all sexes, aged 2 Years or older, up to 21 Years, studying Soft Tissue Sarcoma. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
What phase is the NCT06514313 trial and what does that mean for participants?
Phase 2 trials evaluate whether the treatment shows signs of effectiveness while continuing to monitor safety. More participants are enrolled than in Phase 1 to help refine the treatment protocol.
Is NCT06514313 currently recruiting?
Yes, NCT06514313 is actively recruiting participants. Contact the research team at zhangyzh@sysucc.org.cn for enrollment information.
Where is the NCT06514313 trial being conducted?
This trial is being conducted at Guangzhou, China.
Who is sponsoring the NCT06514313 clinical trial?
NCT06514313 is sponsored by Yizhuo Zhang. The trial plans to enroll 110 participants.