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Recruiting NCT06116656
Changes in Host Gene Expression to Differentiate Between Systemic Inflammation and Infection After Major Surgery
Trial Parameters
Condition Infections
Sponsor St. Antonius Hospital
Study Type OBSERVATIONAL
Phase N/A
Enrollment 150
Sex ALL
Min Age 18 Years
Max Age N/A
Start Date 2024-12-01
Completion 2026-01-01
All Conditions
Interventions
blood leucocyte transcriptomics
Brief Summary
Changes in host gene expression may provide additional information to diagnose postoperative infection and improve outcome after surgery. This study aims to validate the early diagnostic performance of specific gene signatures for differentiating infection from non-infected SIRS or uncomplicated postoperative course in blood sampes of adult patients undergoing major noncardiac surgery.
Eligibility Criteria
Inclusion Criteria: * Age \>18 years * Major noncardiac surgery with infection risk \>20% Exclusion Criteria: * Age \<18 years * Emergency surgery * Inability to provide informed consent.
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