Efficacy and Safety of Antimicrobial Durations Treatment of Infections Associated With Osteosynthesis Material
Trial Parameters
Brief Summary
Infections associated with osteosynthesis material are among the most feared and challenging complications of trauma surgery and can lead to total function loss or limb amputation when complete recovery is to be expected without infection. This is a clinical trial with the purpose of evaluate the optimal duration of antibiotic therapy in Infections Associated With Osteosynthesis Material Implanted when implant is retained.
Eligibility Criteria
Inclusion Criteria: * Age greater than or equal to 14 years. * Stable fracture, even if unconsolidated. * Controlled infection (absence of signs or symptoms of sepsis). * Early or delayed infection. * Availability of antibiotics active against the isolated microorganism. * Absence of bone exposure. Patients who initially had bone exposure but during the debridement surgery bone coverage was performed by any method (skin approximation, grafting, vacuum therapy) can be included in the criteria. * Signed written informed consent. * If there is a possibility of pregnancy (in women of childbearing potential) or paternity, agree to use a highly effective method of birth control recommended by the Clinical Trial Facilitation Group (CTFG) during the treatment phase of the trial Exclusion Criteria: * Late infections * Infections of osteosynthesis material in non-long bones. * Infections of revision osteosynthesis material or occurring after previous surgeries. * Patients who are not expected to