NCT07896642 Brown Adipose Tissue Modulation in Polycystic Ovary Syndrome Using Infrared Thermography
| NCT ID | NCT07896642 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Istanbul Health and Technology University |
| Condition | Polycystic Ovary Syndrome (PCOS) |
| Study Type | INTERVENTIONAL |
| Enrollment | 60 participants |
| Start Date | 2026-11 |
| Primary Completion | 2026-12 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 60 participants in total. It began in 2026-11 with a primary completion date of 2026-12.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
This study will investigate brown adipose tissue-related physiological responses in women with polycystic ovary syndrome (PCOS). Women with PCOS who have normal body mass index, women with PCOS who are overweight or have obesity, and healthy women will be compared. Brown adipose tissue-related heat responses will be evaluated using non-invasive infrared thermography of the supraclavicular region, together with serum UCP-1 levels and metabolic measurements. Participants in the overweight/obesity PCOS group will receive an inositol supplement for 12 weeks, and measurements will be repeated after supplementation. The study will also examine possible relationships between surface temperature responses, dietary intake, physical activity, body measurements, and metabolic and hormonal markers.
Eligibility Criteria
Inclusion Criteria: * Female participants aged 18-40 years * Premenopausal status * Ability and willingness to provide written informed consent * For the Overweight/Obesity PCOS - Inositol and Normal-BMI PCOS Reference Group arms: * Diagnosis of polycystic ovary syndrome (PCOS) established by an obstetrician and gynecologist according to the Rotterdam criteria * For the Normal-BMI PCOS Reference Group arm: * BMI 18.5-24.9 kg/m² * For the Overweight/Obesity PCOS - Inositol arm: * BMI ≥25 kg/m² * For the Healthy Control Group arm: * BMI 18.5-24.9 kg/m² * Regular menstrual cycles * Normal ovarian morphology * No diagnosis of PCOS Exclusion Criteria: * Male sex * Age ≤17 years or ≥41 years * Menopausal status * BMI \<18.5 kg/m² * Pregnancy or breastfeeding * Regular smoking or alcohol consumption * Being highly physically active, defined as regular exercise during the previous 6 months or being a professional athlete * Presence of endocrine disorders that may affect the diagnosis of PCOS, including thyroid disease, congenital adrenal hyperplasia, androgen-secreting tumors, or Cushing syndrome * Any intervention for PCOS treatment within the previous 6 months, including pharmacological treatment or alternative approaches such as acupuncture * History of ovarian surgery * Presence of any of the following conditions: * Secondary hypertension * Cardiovascular, cerebrovascular, renal, hepatic, thyroid, or pulmonary disease * Any type of cancer * Acute infection * Autoimmune disease * Severe psychological or neurological disease * Following a special diet that may affect metabolic rate, including vegetarian, vegan, diabetic, or low-calorie diets * Regular use of dietary supplements such as probiotics or prebiotics * History of obesity-specific treatment, including bariatric surgery or anti-obesity medication * Regular medication use within the previous 3 months or currently, particularly oral contraceptives, hormonal medications, or medications affecting metabolism
Contact & Investigator
Rana Turgut Yaman
PRINCIPAL INVESTIGATOR
Istanbul Health and Technology University
Frequently Asked Questions
Who can join the NCT07896642 clinical trial?
This trial is open to female participants only, aged 18 Years or older, up to 40 Years, studying Polycystic Ovary Syndrome (PCOS). Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07896642 currently recruiting?
Yes, NCT07896642 is actively recruiting participants. Contact the research team at ranaturgut8@hotmail.com for enrollment information.
Where is the NCT07896642 trial being conducted?
This trial is being conducted at Istanbul, Turkey (Türkiye), Istanbul, Turkey (Türkiye).
Who is sponsoring the NCT07896642 clinical trial?
NCT07896642 is sponsored by Istanbul Health and Technology University. The principal investigator is Rana Turgut Yaman at Istanbul Health and Technology University. The trial plans to enroll 60 participants.