NCT07142603 Appetite Response to Meals With Different Protein Sources in Women With PCOS
| NCT ID | NCT07142603 |
| Status | Recruiting |
| Phase | — |
| Sponsor | University of Arkansas, Fayetteville |
| Condition | Polycystic Ovary Syndrome (PCOS) |
| Study Type | INTERVENTIONAL |
| Enrollment | 30 participants |
| Start Date | 2025-08-18 |
| Primary Completion | 2026-12-31 |
Eligibility & Interventions
Eligibility Fast-Check
Enter your details for a quick preliminary check. This does not replace medical advice.
What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 30 participants in total. It began in 2025-08-18 with a primary completion date of 2026-12-31.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
Polycystic ovary syndrome (PCOS) is a common endocrine disorder characterized by insulin resistance, hyperandrogenism, and reproductive dysfunction. Dietary strategies that improve postprandial insulin and glucose responses are central to managing metabolic symptoms in PCOS. Meals higher in protein can attenuate postprandial glycemia and enhance satiety, but the effects may vary by protein source. Animal sources of protein typically have higher essential amino acid content and insulinogenic potential, whereas plant proteins offer fiber and phytochemicals that may influence glycemic dynamics differently. Few studies have directly compared the acute metabolic effects of plant versus animal protein in women with PCOS. Given the distinct pathophysiology of PCOS, extrapolating findings from healthy populations may be misleading. Understanding protein-specific effects on postprandial insulin, glucose, and appetite-regulating hormones in this group is essential for targeted nutrition guidance. Additionally, plant-based diets are increasingly promoted for cardiometabolic health, but their acute effects in insulin-resistant women remain underexplored. This study will assess whether plant and animal protein meals elicit differential postprandial responses in women with PCOS. Findings may inform dietary recommendations aimed at improving metabolic outcomes in this high-risk population.
Eligibility Criteria
Inclusion Criteria: * Females ages 18-50 years * Confirmed diagnosis of PCOS * Body mass index (BMI) between 18.5 and 35 kg/m2 * Stable body weight for at least 3 months (+ 5 pounds) * Willingness to consume both plant- and animal-based protein meals Exclusion Criteria: * Smoking or use of nicotine products * Smoking or use of marijuana products * Food allergies or dietary restrictions incompatible with test meals * Diagnosed diabetes (type 1 or 2) * Use of medications that interfere with study outcomes (e.g., metformin, GLP-1 agonists, etc.)
Contact & Investigator
Jamie I Baum, PhD
PRINCIPAL INVESTIGATOR
University of Arkansas, Fayetteville
Frequently Asked Questions
Who can join the NCT07142603 clinical trial?
This trial is open to female participants only, aged 18 Years or older, up to 50 Years, studying Polycystic Ovary Syndrome (PCOS). Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07142603 currently recruiting?
Yes, NCT07142603 is actively recruiting participants. Contact the research team at baum@uark.edu for enrollment information.
Where is the NCT07142603 trial being conducted?
This trial is being conducted at Fayetteville, United States.
Who is sponsoring the NCT07142603 clinical trial?
NCT07142603 is sponsored by University of Arkansas, Fayetteville. The principal investigator is Jamie I Baum, PhD at University of Arkansas, Fayetteville. The trial plans to enroll 30 participants.