NCT04286516 Brain Connections for Arm Movement After Stroke
| NCT ID | NCT04286516 |
| Status | Recruiting |
| Phase | — |
| Sponsor | VA Office of Research and Development |
| Condition | Stroke |
| Study Type | INTERVENTIONAL |
| Enrollment | 76 participants |
| Start Date | 2020-01-10 |
| Primary Completion | 2026-09-01 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 76 participants in total. It began in 2020-01-10 with a primary completion date of 2026-09-01.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
The purpose of this study is to use Transcranial Magnetic Stimulation (TMS) while subjects are making reaching movements in a robotic arm device in order to discover how different brain areas control movement before and after stroke and when these brain areas are most sensitive to TMS.
Eligibility Criteria
Inclusion Criteria: Inclusion Criteria (control participants): * Be 45-90 years of age * Have adequate language and neurocognitive function to participate in training and testing * Be medically stable to participate in the study * Be English speaking Inclusion Criteria (participants with stroke): * Be 45-90 years of age * Clinically defined, unilateral, hemiparetic stroke with radiologic exclusion of other possible diagnosis * Stroke onset at least 6 months before enrollment * Subcortical stroke (ex: internal capsule, deep white matter of posterior frontal lobe) * Present with mild to moderate arm dysfunction * Be medically stable to participate in the study * Be English speaking Exclusion Criteria: (for both groups) * Unable to give informed consent * Have a serious complicating medical illness that would preclude participation * Contractures or orthopedic problems limiting range of joint motion in the potential study arm or other impairments that would interfere with the study activities * Visual loss such that the subject would not be able to see the test patterns on the robot computer monitor * Unable to comply with requirements of the study * Enrollment in another greater-than-minimal risk study * Presence of medical condition or implant that prevents safe administration of TMS or MRI * Pregnancy
Contact & Investigator
George F. Wittenberg, MD PhD
PRINCIPAL INVESTIGATOR
VA Pittsburgh Healthcare System University Drive Division, Pittsburgh, PA
Frequently Asked Questions
Who can join the NCT04286516 clinical trial?
This trial is open to participants of all sexes, aged 45 Years or older, up to 90 Years, studying Stroke. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT04286516 currently recruiting?
Yes, NCT04286516 is actively recruiting participants. Contact the research team at amy.boos2@va.gov for enrollment information.
Where is the NCT04286516 trial being conducted?
This trial is being conducted at Pittsburgh, United States.
Who is sponsoring the NCT04286516 clinical trial?
NCT04286516 is sponsored by VA Office of Research and Development. The principal investigator is George F. Wittenberg, MD PhD at VA Pittsburgh Healthcare System University Drive Division, Pittsburgh, PA. The trial plans to enroll 76 participants.
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