Bayesian Neurobehavioral Phenotyping: From Mechanism Identification to Personalized Neuromodulation Treatments. R61 PHASE
Trial Parameters
Brief Summary
The goal of this clinical research study is to learn more about whether individual differences in brain responses to emotional triggers impact rTMS (repetitive transcranial magnetic stimulation) responses in people who smoke.
Eligibility Criteria
Inclusion Criteria: 1. Age 21 to 60 years 2. Report smoking on average, 5 or more cigarettes, little cigars and/or cigarillos per day, within the past 30 days preceding the screening visit. 3. Expired carbon monoxide (CO) ≥ 6ppm and/or test positive for cotinine using a urine cotinine test on day of study visit. 4. Able to follow verbal and written instructions in English and complete all aspects of the study. 5. Have an address and telephone number where they may be reached. 6. Subjects must report current stable residence. Stable residence is a domicile in which an individual can operate as if it were their own homestead and does not include shelters, halfway houses, treatment centers, or group homes. 7. Meet safety criteria for EEG. 8. Be willing to vape from an e-cigarette during specified tasks. 9. Meet safety criteria for rTMS. Note that if a participant is not eligible for rTMS but is eligible for EEG, they may complete the EEG portion of the study. 10. Willing and able to indep