NCT03476551 Bariatric Surgery and Pharmacokinetics of Hydrochlorothiazide
| NCT ID | NCT03476551 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Norwegian University of Science and Technology |
| Condition | Obesity, Morbid |
| Study Type | OBSERVATIONAL |
| Enrollment | 12 participants |
| Start Date | 2016-11-02 |
| Primary Completion | 2026-10 |
Trial Parameters
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Brief Summary
Changes to gastric pH, gastric emptying time, gastrointestinal transit-time or the pre-systemic metabolizing effect of enzymes secreted in the mucosa may all alter the pharmacokinetics of medicines. These factors are potentially influenced by bariatric surgery. Little is so far known about how gastric bypass and sleeve gastrectomy impacts the biological availability of medication. In this study the pharmacokinetic effects of bariatric surgery on hydrochlorothiazide are investigated.
Eligibility Criteria
Inclusion Criteria: * Preparing to undergo gastric bypass or sleeve gastrectomy in Central Norway * Being a Norwegian citizen Exclusion Criteria: * Having previously undergone resections in the GI-tract
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