NCT06698718 Application of CIELab Spectrophotometry to Analyze Gingival Color: a New Perspective for Evaluating the Effectiveness of Periodontal Basic Treatment
| NCT ID | NCT06698718 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Second Affiliated Hospital, Zhejiang University, School of Medicine |
| Condition | Periodontitis |
| Study Type | INTERVENTIONAL |
| Enrollment | 30 participants |
| Start Date | 2024-10-18 |
| Primary Completion | 2025-03-01 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 30 participants in total. It began in 2024-10-18 with a primary completion date of 2025-03-01.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
Objective: This study aims to explore the correlation between gingival color and clinical indicators and inflammatory factors in patients with periodontitis. Method: This study aims to include 30 periodontitis patients who visited the Periodontology Department of the Second Affiliated Hospital of Zhejiang University School of Medicine from October 2024 to November 2024. The study adopted a self controlled before and after design. All subjects received periodontal basic treatment. Record the age, gender, ethnicity, skin color, and gingival biotype of the subjects. Before treatment, 6 weeks after treatment, and 12 weeks after treatment, check and record the blood routine, high-sensitivity C-reactive protein (Hs CRP), and interleukin-6 (IL-6) of all subjects. Use a moisture absorbing paper tip to collect the gingival crevicular fluid of the subjects, and further detect the levels of interleukin-17 (IL-17) and tumor necrosis factor alpha (TNF - α) in the gingival crevicular fluid samples, and record the periodontal table. Check and record the CIE indicators L \*, a \*, b \*, probing depth (PD), gingival bleeding index (SBI), and clinical attachment loss (CAL) in the keratinized gingival area of all subjects before and after treatment at 2, 6, and 12 weeks. Analyze and compare the changes in each group's data before and after treatment.
Eligibility Criteria
Inclusion Criteria: 1. Patients of Han ethnicity, aged between 18 and 65 years old, diagnosed with periodontitis 2. I haven't received any periodontal basic treatment, including scaling, scraping, flap surgery, etc., for the past six months 3. The anterior teeth area has not undergone periodontal surgery or coronal restoration within six months 4. The patient has clear thinking, unobstructed communication, and high compliance Exclusion Criteria: 1. Cardiac function levels III and IV 2. Blood pressure\>180/110 mmHG 3. Pregnant women, women in pregnancy or lactation 4. Those who are currently taking anticoagulant drugs, calcium channel blockers, immunosuppressants, angiotensin and other medications, receiving bisphosphonates treatment, or have a history of antibacterial treatment within 3 months 5. Uncontrolled and stable patients with systemic diseases, such as progressive liver diseases, infectious diseases, renal failure, rheumatoid diseases, blood system diseases, osteoporosis, AIDS, mental diseases and diabetes, etc 6. Patients with malignant tumors or undergoing radiotherapy, chemotherapy, and targeted drug therapy 7. Patients with pacemakers who cannot undergo ultrasound therapy 8. Smoking or quitting smoking for less than 5 years 9. Individuals with abnormalities such as pigment deposition and keratinized beads in the front teeth and gums
Contact & Investigator
Frequently Asked Questions
Who can join the NCT06698718 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, up to 65 Years, studying Periodontitis. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT06698718 currently recruiting?
Yes, NCT06698718 is actively recruiting participants. Contact the research team at weiliansun@zju.edu.cn for enrollment information.
Where is the NCT06698718 trial being conducted?
This trial is being conducted at Hangzhou, China.
Who is sponsoring the NCT06698718 clinical trial?
NCT06698718 is sponsored by Second Affiliated Hospital, Zhejiang University, School of Medicine. The trial plans to enroll 30 participants.