NCT07058467 Anterior Cruciate Ligaments: Studying Updates in neuroCognition After Knee Manipulation
| NCT ID | NCT07058467 |
| Status | Recruiting |
| Phase | — |
| Sponsor | University of North Carolina, Chapel Hill |
| Condition | Anterior Cruciate Ligament (ACL) Tear |
| Study Type | INTERVENTIONAL |
| Enrollment | 30 participants |
| Start Date | 2025-08-01 |
| Primary Completion | 2026-05-31 |
Trial Parameters
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Brief Summary
This study will investigate whether knee joint manipulation can improve neurocognitive and neuromuscular performance in individuals with a history of anterior cruciate ligament reconstruction (ACLR). Recruitment will consist of 30 participants aged 18-35 who are 4 months to 5 years post-ACLR and demonstrate measurable reaction time delays. Using a within-subject pre-post design, participants will complete a battery of neurocognitive and neuromuscular assessments, including visuomotor reaction time and dual-task hop testing, before and after knee joint manipulation(s). The main questions the investigators aim to address are: Aim 1: Evaluate the feasibility, acceptability, and applicability of integrating knee joint manipulation into post-ACLR rehabilitation using the Implementation and Outcomes Framework. Aim 2: Determine preliminary efficacy of knee joint manipulation on neurocognitive performance in individuals with ACLR.
Eligibility Criteria
Inclusion Criteria: * Provided informed consent prior to any study procedures that are performed. * Are between the ages of 18 and 35. * Have undergone ACLR surgery. All autograft and allograft types are accepted. * Are 4-months to 10-years post-ACLR. * Injured knee playing or training for sports (recreational or organized) or during physical activity. * Have been cleared by a physician to return to activities and/or participate in this study. * Are at least the minimally clinical important difference (MCID) above the normative reaction time average for our methods as established by previous literature in at least 1 reaction time task. Exclusion Criteria: * History of concussion in the past 3 months. * The participant is pregnant. * Have a neurological disorder, including epilepsy. * Currently injured or have injured their lower extremity in the past 3 months. * Had surgery on multiple ligaments when their ACL was injured.