NCT06370312 Analysis of Articular Biomarkers From Osteoarthritic Thumb Basal Joints
| NCT ID | NCT06370312 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Region Skane |
| Condition | Osteoarthritis Thumb |
| Study Type | OBSERVATIONAL |
| Enrollment | 120 participants |
| Start Date | 2024-05-01 |
| Primary Completion | 2026-04-30 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
This is an observational study. You will not receive an experimental treatment; researchers will collect data based on your existing condition or standard treatment.
This trial targets 120 participants in total. It began in 2024-05-01 with a primary completion date of 2026-04-30.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
The study project aims at examining molecular markers in synovial fluid, bone and articular cartilage from osteoarthritic thumb basal joints. The degradation of extracellular matrix (ECM) proteins in thumb basal joints will be evaluated in association to the metabolic profile of the patient, but we also aim to compare the ECM degradation and inflammatory profiles with articular cartilage degradation ECM profile from knee joints with osteoarthritis. A third aim is to evaluate associations between patient-reported hand function, pain, strength and range of thumb motion to analyses of synovial fluid.
Eligibility Criteria
Inclusion Criteria: * Men and women age ≥ 25 years * Radiologically confirmed and symptomatic thumb basal joint osteoarthritis (OA) planned for trapeziectomy Exclusion Criteria: * Previous surgery to the affected thumb basal joint * Post-traumatic thumb basal joint OA * Rheumatoid arthritis or other chronic inflammatory arthritis, history of psoriasis affecting joints, gout or pseudogout * Ongoing infection in the hand or wrist * Inability to co-operate with the follow-up protocol or to assimilate information about the study protocol (language difficulties, severe psychiatric disorder, cognitive impairment, drug addiction) * Systemic or intra-articular glucocorticoids or intraarticular platelet-rich plasma or hyaluronic acid injections in the affected joint within 3 months prior to enrollment
Contact & Investigator
Elisabeth Brogren, MD, PhD
PRINCIPAL INVESTIGATOR
Department of hand surgery, Region Skåne
Frequently Asked Questions
Who can join the NCT06370312 clinical trial?
This trial is open to participants of all sexes, aged 25 Years or older, studying Osteoarthritis Thumb. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT06370312 currently recruiting?
Yes, NCT06370312 is actively recruiting participants. Contact the research team at elisabeth.brogren@med.lu.se for enrollment information.
Where is the NCT06370312 trial being conducted?
This trial is being conducted at Malmö, Sweden, Malmö, Sweden.
Who is sponsoring the NCT06370312 clinical trial?
NCT06370312 is sponsored by Region Skane. The principal investigator is Elisabeth Brogren, MD, PhD at Department of hand surgery, Region Skåne. The trial plans to enroll 120 participants.