NCT06886945 An Integrated Neurophysiological Approach Toward the Early Detection of Psychiatric Disorders
| NCT ID | NCT06886945 |
| Status | Recruiting |
| Phase | — |
| Sponsor | IRCCS Centro San Giovanni di Dio Fatebenefratelli |
| Condition | Schizophrenia Disorders |
| Study Type | OBSERVATIONAL |
| Enrollment | 75 participants |
| Start Date | 2024-04-09 |
| Primary Completion | 2025-10 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
This is an observational study. You will not receive an experimental treatment; researchers will collect data based on your existing condition or standard treatment.
This trial targets 75 participants in total. It began in 2024-04-09 with a primary completion date of 2025-10.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
Schizophrenia (SCZ) is a severe neuropsychiatric disorder characterized by cognitive decline, social withdrawal, and positive symptoms such as hallucinations and delusions. Research suggests that SCZ and schizotypy exist along a continuum, with shared structural and behavioral abnormalities, the latter of which encompass the sensory and perceptual domain, often in the form of altered multisensory integration, as seen in tasks like the Sound-Induced Flash Illusion (SIFI). Individuals with schizotypal traits or SCZ show enlarged temporal binding windows (TBW) of cross-modal integration, affecting perceptual accuracy and multisensory judgments. However, whether these deficits stem from overactive top-down modulation or weakened bottom-up sensory precision remains unclear. The current study seeks to address these questions, by asking participants (healthy individuals screened as for their schizotypal traits, and patients suffering from SCZ) to complete a modified version of the SIFI, as well as an audiovisual temporal order judgment (TOJ) task. Cross-modal performance will be assessed via signal detection theory (SDT) metrics and psychometric modeling to estimate individual TBWs, thereby assaying audiovisual processing abilities along the schizotypal continuum
Eligibility Criteria
Inclusion Criteria (all participants): * Normal hearing * Normal or corrected-to-normal vision Inclusion Criteria (patients): * Clinical diagnosis of schizophrenia spectrum disorder (according to DSM-5) * IQ \> 70 Exclusion Criteria (all participants): * Anamnesis or evidence of any central nervous system alteration Exclusion Criteria (patients) * Current major physical illness * Drug dependency/abuse over the last 6 months * Unstable pharmacological therapy * Comorbidities with other major psychiatric disorders
Frequently Asked Questions
Who can join the NCT06886945 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, up to 50 Years, studying Schizophrenia Disorders. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT06886945 currently recruiting?
Yes, NCT06886945 is actively recruiting participants. Visit ClinicalTrials.gov or contact IRCCS Centro San Giovanni di Dio Fatebenefratelli to inquire about joining.
Where is the NCT06886945 trial being conducted?
This trial is being conducted at Brescia, Italy.
Who is sponsoring the NCT06886945 clinical trial?
NCT06886945 is sponsored by IRCCS Centro San Giovanni di Dio Fatebenefratelli. The trial plans to enroll 75 participants.
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