Schizophrenia trials have been revitalized by the approval of muscarinic receptor agonists (xanomeline-trospium/KarXT) — the first non-dopaminergic antipsychotic approved in decades — validating a long-hypothesized cholinergic mechanism and opening new mechanistic territory. Negative symptom treatment and cognitive impairment associated with schizophrenia (CIAS) remain critical unmet needs with no approved therapies.
Active trials investigate M1/M4 muscarinic agonists, trace amine-associated receptor 1 (TAAR1) agonists (ulotaront), glycine transporter inhibitors, cognitive remediation combined with pharmacotherapy, and long-acting injectable formulations to improve adherence. PANSS total score and negative symptom subscales are standard primary endpoints.
Frequently Asked Questions — schizophrenia disorders Clinical Trials
How many clinical trials are currently recruiting for schizophrenia disorders?
ClinicalMetric currently tracks 2 actively recruiting clinical trials for schizophrenia disorders, sourced in real time from ClinicalTrials.gov. The total number of registered studies—including those not yet enrolling or in active follow-up—is 2. Trial availability changes daily as new studies open enrollment and existing ones reach capacity.
What trial phases are available for schizophrenia disorders?
schizophrenia disorders research spans multiple clinical trial phases. Phase 1 studies evaluate safety and dosing in small groups, Phase 2 studies assess preliminary efficacy in 100–300 participants, and Phase 3 trials compare the new treatment against the standard of care in 300–3,000+ patients. Phase 4 post-approval studies monitor long-term outcomes in real-world populations.
How do I find out if I qualify for a schizophrenia disorders clinical trial?
Eligibility criteria for schizophrenia disorders trials vary by study and typically specify age range, disease stage or severity, prior treatment history, and specific diagnostic or laboratory parameters. Each listing on ClinicalMetric links to the full protocol on ClinicalTrials.gov, where inclusion and exclusion criteria are documented. Contact the sponsoring site's research coordinator directly to confirm your eligibility—your treating physician or specialist can also help identify the most appropriate trial based on your medical history and current treatment status.
Top Sponsors
Kastamonu University 1 trial
University of Rochester 1 trial
Recruiting Clinical Trials
ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional.
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Last Reviewed: April 2026 ·
Data Methodology