NCT06749392 An Individual-specific Synchrony Signature
| NCT ID | NCT06749392 |
| Status | Recruiting |
| Phase | — |
| Sponsor | University of Haifa |
| Condition | Major Depressive Disorder |
| Study Type | INTERVENTIONAL |
| Enrollment | 78 participants |
| Start Date | 2025-11-22 |
| Primary Completion | 2030-03-30 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 78 participants in total. It began in 2025-11-22 with a primary completion date of 2030-03-30.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
This study aims to establish synchrony as an individual-specific mechanism of therapeutic change and offers novel insights into the mechanisms of curative interpersonal processes. The study identifies individual-specific trait-like synchrony signature and investigates the associations between synchrony signature, the individual's trait-like characteristics, and mental health, among participants diagnosed with Major Depressive Disorder. The study further investigates how deterministic the trait-like synchrony signature is by identifying for whom, how, and when changes are anticipated. Additionally, it examines whether synchrony signature transfers to relationships with the therapist, whether and how it changes throughout treatment, and whether such potential changes are associated with improvements in mental health. Synchrony is recognized as a key driver of collaborative, affiliative, and curative relationships. While its potential role in improving mental health through interpersonal relationships has sparked growing interest, particularly in psychotherapy, the field is at a crossroads, with mixed findings challenging the widespread theoretical assumption that "more synchrony is better." This study introduces a personalized framework that emphasizes individual-specific synchrony signatures, shifting from generalized assumptions to tailored understanding and interventions. The study explores how synchrony can transform relationships into curative ones by leveraging individual-tailored changes in synchrony signatures in psychotherapy. The potential impact is vast. Tailoring synchrony to individual-specific signatures represents a paradigm shift from a one-size-fits-all approach to personalized interventions. This personalized framework could revolutionize mental health care by facilitating the development of targeted strategies that enhance treatment outcomes.
Eligibility Criteria
Inclusion Criteria: * Current major depressive disorder based on the Diagnostic and Statistical Manual of Mental Disorders-5, and scores above 14 on the 17-item Hamilton rating scale for depression at two consecutive assessments, one week apart. * For participants using psychiatric medication, the dosage must be stable for at least three months before the beginning of the study, and they will be asked to maintain stable dosage during the treatment * Age between 18 and 65 years * Hebrew language proficiency * Provision of written informed consent. Exclusion Criteria: * Current risk of suicide or self-harm * Current substance abuse disorders * Current or past schizophrenia or psychosis, bipolar disorder, or severe eating disorder requiring medical monitoring * History of organic mental disease * Currently in psychotherapy
Contact & Investigator
Frequently Asked Questions
Who can join the NCT06749392 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, up to 65 Years, studying Major Depressive Disorder. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT06749392 currently recruiting?
Yes, NCT06749392 is actively recruiting participants. Contact the research team at sigalzil@gmail.com for enrollment information.
Where is the NCT06749392 trial being conducted?
This trial is being conducted at Haifa, Israel.
Who is sponsoring the NCT06749392 clinical trial?
NCT06749392 is sponsored by University of Haifa. The trial plans to enroll 78 participants.