NCT06619405 AMD and Validation Rod-Meditated Dark Adaptation With Everyday Task Performance
| NCT ID | NCT06619405 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Duke University |
| Condition | Age-Related Macular Degeneration |
| Study Type | INTERVENTIONAL |
| Enrollment | 100 participants |
| Start Date | 2025-08-15 |
| Primary Completion | 2026-12-31 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 100 participants in total. It began in 2025-08-15 with a primary completion date of 2026-12-31.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
The goal is to conduct a cross-sectional, single timepoint study on older adults with early and intermediate AMD, and with subretinal drusenoid deposits (SDD), and those in normal health, establishing an association between dark adaptation and reading performance under dim illumination, both which depend on rod photoreceptors.
Eligibility Criteria
Inclusion Criteria: * Capable and willing to provide consent * Has been diagnosed with early, intermediate dry age-related macular degeneration or geographic atrophy or has a healthy macular for controls * At least 50 years of age Exclusion Criteria: * Unable or unwilling to give consent or unable to read consent since the study involves testing which requires reading * Under 50 years of age * Presence of dense cataracts in the study eye (s) that can affect visual function tests * Presence of glaucoma requiring treatment during the study and/or visual field defects * Previous retinal laser or surgical therapy in the study eye(s) * Previous retinal laser or surgical therapy in the study eye(s) * Any other ocular condition requiring long-term therapy or surgery during the study * The participant has photographically significant corneal or media opacities in either eye that would preclude adequate ophthalmic imaging and functional testing * Diagnosis of nystagmus that will interfere with testing * High myopia -8 Diopters or more severe * The participant has, in the opinion of the Investigator, any physical or mental condition that would increase the risk of participation in the study or may interfere with the study procedures, evaluations, and outcome assessments.
Contact & Investigator
Eleonora Lad, MD, PhD
PRINCIPAL INVESTIGATOR
Duke University
Frequently Asked Questions
Who can join the NCT06619405 clinical trial?
This trial is open to participants of all sexes, aged 50 Years or older, up to 89 Years, studying Age-Related Macular Degeneration. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT06619405 currently recruiting?
Yes, NCT06619405 is actively recruiting participants. Contact the research team at nora.lad@duke.edu for enrollment information.
Where is the NCT06619405 trial being conducted?
This trial is being conducted at Durham, United States.
Who is sponsoring the NCT06619405 clinical trial?
NCT06619405 is sponsored by Duke University. The principal investigator is Eleonora Lad, MD, PhD at Duke University. The trial plans to enroll 100 participants.