NCT05865470 Age-dependent Effects of Smoked and Oral Delta-9-THC
| NCT ID | NCT05865470 |
| Status | Recruiting |
| Phase | Phase 1 |
| Sponsor | University of California, Los Angeles |
| Condition | Pain |
| Study Type | INTERVENTIONAL |
| Enrollment | 103 participants |
| Start Date | 2025-04-30 |
| Primary Completion | 2028-10-15 |
Trial Parameters
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Brief Summary
This study will assess the age-dependent effects of smoked and oral THC on abuse liability, intoxication, analgesia and impairment as a function of age.
Eligibility Criteria
Inclusion Criteria: * Male or non-pregnant female aged 18-65 years according to the below criteria: EMERGING ADULTS: 18-25 years of age (+/- one year) MIDDLE-AGED ADULTS: 35-45 years of age (+/- one year) LATE MIDDLE-AGED ADULTS: 55-65 years of age (+/- one year) * Report weekly-monthly use of cannabis (with primary mode of use via inhalation) over the past 6 months prior to screening * Not currently seeking treatment for their cannabis use * No reported clinically significant adverse effects with cannabis use * Have a Body Mass Index from 18.5 - 34kg/m2 * Able to perform all study procedures * FEMALES: Currently practicing an effective form of birth control if pre-menopausal Exclusion Criteria: * Meeting DSM-5 (Diagnostic and Statistical Manual of Mental Disorders-5) criteria for any substance use disorder other than nicotine and mild cannabis use disorder * Report using other illicit drugs in the prior 4 weeks * Evidence of severe psychiatric illness (e.g. mood disorder with function