NCT07103902 Aerobic Exercise and Obsessive-Compulsive Disorder Symptoms
| NCT ID | NCT07103902 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Yale University |
| Condition | Obsessive-Compulsive Disorder (OCD) |
| Study Type | INTERVENTIONAL |
| Enrollment | 50 participants |
| Start Date | 2026-02-16 |
| Primary Completion | 2026-09-01 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 50 participants in total. It began in 2026-02-16 with a primary completion date of 2026-09-01.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
The purpose of this study is to examine the acute effects of exercise on cognitive flexibility and symptom reactivity. The main questions it aims to answer are: Does moderate intensity physical activity reduce subjective distress, compulsive urges, and intrusions- and increase cognitive flexibility- in adults with obsessive-compulsive disorder compared to low-intensity physical activity? Researchers will compare low- to moderate-intensity exercise to see if moderate physical activity increases cognitive flexibility and reduces symptom reactivity in adults with obsessive-compulsive disorder (OCD). Participants will: Complete self-report surveys, psychiatric interviews, and cognitive tasks. Be assigned to either a low- or moderate-intensity exercise condition and complete physical activity. Repeat cognitive and symptom measures following the exercise intervention.
Eligibility Criteria
Inclusion Criteria: * Adults, age 18 to 64 years * Meet diagnostic criteria for OCD (per the DIAMOND) * Stable psychiatric or medication treatment (if ≥4-weeks), or if no active treatment. Psychotropic medications will be reviewed with the study psychiatrist on a case by case basis. Exclusion Criteria: * Active or unmanaged psychotic disorders, pervasive developmental disorders, bipolar disorder, current substance use disorder (moderate-to-severe), or high risk for suicide (defined as attempt, plan, or intent within past 3 months) * Documented motor impairments and medical condition(s) that prohibit physical exercise * Those who are pregnant or trying to become pregnant
Contact & Investigator
Frequently Asked Questions
Who can join the NCT07103902 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, up to 64 Years, studying Obsessive-Compulsive Disorder (OCD). Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07103902 currently recruiting?
Yes, NCT07103902 is actively recruiting participants. Contact the research team at emily.weiss@yale.edu for enrollment information.
Where is the NCT07103902 trial being conducted?
This trial is being conducted at New Haven, United States.
Who is sponsoring the NCT07103902 clinical trial?
NCT07103902 is sponsored by Yale University. The trial plans to enroll 50 participants.