| NCT ID | NCT07464080 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Ottawa Hospital Research Institute |
| Condition | Knee Osteoarthritis (Knee OA) |
| Study Type | INTERVENTIONAL |
| Enrollment | 50 participants |
| Start Date | 2026-04-01 |
| Primary Completion | 2027-12-31 |
Eligibility & Interventions
Eligibility Fast-Check
Enter your details for a quick preliminary check. This does not replace medical advice.
What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 50 participants in total. It began in 2026-04-01 with a primary completion date of 2027-12-31.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
Knee replacement surgery is a common and effective treatment for pain and mobility loss, yet up to 1 in 5 patients remain dissatisfied after surgery due to ongoing pain or difficulty with daily activities. Currently, clinicians cannot reliably predict which patients will experience these challenges. This study uses MRI scan of the brain to investigate whether specific patterns of brain activity can predict patient satisfaction after total knee arthroplasty (TKA). By comparing brain networks before surgery and afterward, and linking these changes to patient-reported pain and function, we aim to identify brain-based markers that can help predict outcomes, to improve satisfaction after knee replacement surgery.
Eligibility Criteria
Inclusion Criteria: 1. Male and female patients aged 18 years or older 2. Primary TKA 3. Diagnosis of osteoarthritis, inflammatory arthritis, or osteonecrosis Exclusion Criteria: 1. Inability or refusal to sign informed consent form 2. Non-English or French speaking, and no licensed translator, family member or substitute decision maker available 3. History of major neurological disorders (e.g traumatic brain injury, epilepsy, multiple sclerosis 4. Cognitive impairment or dementia 5. Revision and/or Bilateral TKA 6. Chronic Opioid use
Contact & Investigator
Simon Garceau
PRINCIPAL INVESTIGATOR
The Ottawa Hospital
Frequently Asked Questions
Who can join the NCT07464080 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, studying Knee Osteoarthritis (Knee OA). Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07464080 currently recruiting?
Yes, NCT07464080 is actively recruiting participants. Contact the research team at scosta@ohri.ca for enrollment information.
Where is the NCT07464080 trial being conducted?
This trial is being conducted at Ottawa, Canada.
Who is sponsoring the NCT07464080 clinical trial?
NCT07464080 is sponsored by Ottawa Hospital Research Institute. The principal investigator is Simon Garceau at The Ottawa Hospital. The trial plans to enroll 50 participants.