NCT05686798 Adenovirus Mediated Suicide Gene Therapy With Radiotherapy in Progressive Astrocytoma.
| NCT ID | NCT05686798 |
| Status | Recruiting |
| Phase | Phase 1 |
| Sponsor | Henry Ford Health System |
| Condition | Malignant Glioma of Brain |
| Study Type | INTERVENTIONAL |
| Enrollment | 18 participants |
| Start Date | 2022-11-29 |
| Primary Completion | 2027-01 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
Phase 1 is the earliest stage of human testing — safety and dosage are the primary focus. Visits are frequent and medical supervision is intensive. You will be among the first people to receive this treatment.
This trial targets 18 participants in total. It began in 2022-11-29 with a primary completion date of 2027-01.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
The primary goal of this Phase I study is to determine the maximum tolerated dose of oncolytic adenovirus mediated double suicide-gene therapy in combination with fractionated stereotactic radiosurgery in patients with recurrent high-grade astrocytoma undergoing resection.
Eligibility Criteria
Inclusion Criteria: 1. Subjects with radiologic evidence of intracranial recurrence or progression of a previously diagnosed high-grade astrocytoma. To be eligible for this trial, the subjects must have: * Histologically documented glioblastomas or anaplastic astrocytoma prior to the debulking surgery that is suspicious to have progressed on imaging. An interval of at least 3 months must have elapsed since the completion of the most recent course of radiation while at least 4 weeks must have elapsed since the completion of a non-nitrosourea containing chemotherapy regimen and at least 6 weeks since the completion of a nitrosourea containing chemotherapy regimen. * Patients must be ≥ 18 years of age, able to provide informed consent and express a willingness to meet all the expected requirements of the protocol for the duration of the study. * Must have recovered from toxicity (grade 2 or less) of prior therapy. * Eligible for partial or total resection of the recurrent tumor * No anticipated physical connection between post-resection tumor cavity and cerebral ventricle * Karnofsky performance status (KPS) ≥ 60 at time of surgery * No prior treatment of the tumor with gene or virus therapy, immunotherapy, brachytherapy, or implants of polymers containing chemotherapeutic agents (e.g. Gliadel Wafer) * No immunosuppressive or immune disorder * Baseline organ function testing intact * Patients who are candidates for surgical debulking (re-resection) following recurrence of diseases based on multidisciplinary evaluation by neurosurgeons, radiation oncologists, neuro-radiologists, and neuro-oncologists. 2. Subjects must have adequate baseline organ function, as assessed by the following laboratory values, within 30 days before initiating the study therapy: * Adequate renal function with creatinine clearance ≥ 50 mL/min/m2 * Platelet count ≥ 100,000/μL * Absolute neutrophil count ≥ 1,000/μL * Hemoglobin \> 10.0 g/dL * Bilirubin \< 1.5 mg/dL; SGOT and SGPT \< 2.5 times upper limit of normal (ULN). 3. Women of child-bearing potential will be required to practice birth control for the duration of the treatment and for at least 90 days after surgery with intratumor virus inoculation. Men must use barrier protection for the duration of treatment and for at least 90 days after surgery with intratumor virus inoculation treatment. Exclusion Criteria: * Acute infection. Acute infection is defined by any viral, bacterial, or fungal infection that has required active treatment and caused oral temperature \>38.5oC and/or clinically significant leukocytosis * Serum antibodies to human immunodeficiency virus (HIV) * Previous history of liver disease including autoimmune or viral hepatitis * Positive serologic test for Hepatitis B or C at baseline * Immunosuppressive therapy except for corticosteroid use * Serious medical or psychiatric illness or concomitant medication, which, in the judgment of the investigator, might interfere with the subject's ability to respond to or tolerate the treatment or complete the trial * Impaired immunity or susceptibility to serious viral infections * Pregnant or lactating females * Allergy to any product used on the protocol * Patient is not able to undergo a brain MRI. * Patients who are not eligible for debulking surgery or resection of recurrent disease will be considered ineligible.
Contact & Investigator
Tobias Walbert, MD, PhD
PRINCIPAL INVESTIGATOR
Henry Ford Health System
Frequently Asked Questions
Who can join the NCT05686798 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, studying Malignant Glioma of Brain. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
What phase is the NCT05686798 trial and what does that mean for participants?
Phase 1 trials are the first stage of human testing. The primary goal is to assess safety and determine appropriate dosage levels. Participants are closely monitored. These trials typically involve a small number of volunteers.
Is NCT05686798 currently recruiting?
Yes, NCT05686798 is actively recruiting participants. Contact the research team at twalber1@hfhs.org for enrollment information.
Where is the NCT05686798 trial being conducted?
This trial is being conducted at Detroit, United States.
Who is sponsoring the NCT05686798 clinical trial?
NCT05686798 is sponsored by Henry Ford Health System. The principal investigator is Tobias Walbert, MD, PhD at Henry Ford Health System. The trial plans to enroll 18 participants.