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Medical Condition

glioma

Total Trials
23
Recruiting Now
23
Trial Phases
EARLY_Phase 1, Phase 1, Phase 3

ClinicalMetric tracks all active clinical trials for glioma sourced from ClinicalTrials.gov. Each listing includes the NCT identifier, current recruitment status, phase, primary endpoints, sponsor, estimated enrollment, and participating countries — updated daily as new studies open and status changes.

  • Recruiting trials currently enrolling participants, with eligibility criteria and age requirements
  • Phase 1–4 studies from early safety trials to post-marketing surveillance
  • NIH, pharmaceutical sponsor, and academic medical center studies worldwide
  • AI-powered plain-language summary available for every trial listing

Frequently Asked Questions — glioma Clinical Trials

How many clinical trials are currently recruiting for glioma?
ClinicalMetric currently tracks 23 actively recruiting clinical trials for glioma, sourced in real time from ClinicalTrials.gov. The total number of registered studies—including those not yet enrolling or in active follow-up—is 23. Trial availability changes daily as new studies open enrollment and existing ones reach capacity.
What trial phases are available for glioma?
glioma research spans Phase 1 (6 trials), Phase 2 (4 trials), Phase 3 (3 trials), Phase 4 (1 trial). Phase 1 studies evaluate safety and dosing in small groups, Phase 2 studies assess preliminary efficacy in 100–300 participants, and Phase 3 trials compare the new treatment against the standard of care in 300–3,000+ patients. Phase 4 post-approval studies monitor long-term outcomes in real-world populations.
How do I find out if I qualify for a glioma clinical trial?
Eligibility criteria for glioma trials vary by study and typically specify age range, disease stage or severity, prior treatment history, and specific diagnostic or laboratory parameters. Each listing on ClinicalMetric links to the full protocol on ClinicalTrials.gov, where inclusion and exclusion criteria are documented. Contact the sponsoring site's research coordinator directly to confirm your eligibility—your treating physician or specialist can also help identify the most appropriate trial based on your medical history and current treatment status.
Trial Phases
Phase 1
6
Phase 2
4
Phase 3
3
Phase 4
1
Top Sponsors
Mayo Clinic 2 trials
M.D. Anderson Cancer Center 2 trials
Massachusetts General Hospital 1 trial
Henry Ford Health System 1 trial
Baptist Health South Florida 1 trial

Recruiting Clinical Trials

NCT07025226 EARLY_Phase 1
Recruiting

Sequential Treatments or Combinations Including Dasatinib, Quercetin, Fisetin and/or Temozolomide for the Treatment of Previously Treated Glioma With Residual Disease

Enrollment
10 pts
Location
United States
Sponsor
Mayo Clinic
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NCT06099743
Recruiting

ASCENT Intervention for Brain Tumor Patients

Enrollment
100 pts
Location
United States
Sponsor
Massachusetts General Hospital
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NCT05686798 Phase 1
Recruiting

Adenovirus Mediated Suicide Gene Therapy With Radiotherapy in Progressive Astrocytoma.

Enrollment
18 pts
Location
United States
Sponsor
Henry Ford Health System
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NCT06397560
Recruiting

PrOton Pulsed reduCed dOse Rate Radiotherapy for Recurrent CNS maligNancies Trial

Enrollment
28 pts
Location
United States
Sponsor
Baptist Health South Florida
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NCT05580562 Phase 3
Recruiting

ONC201 in H3 K27M-mutant Diffuse Glioma Following Radiotherapy (the ACTION Study)

Enrollment
510 pts
Location
United States, Argen...
Sponsor
Jazz Pharmaceuticals
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NCT07486713 Phase 4
Recruiting

Olutasidenib DDI Study in Patients With IDH1 Mutation Positive Malignancies

Enrollment
16 pts
Location
United States
Sponsor
Rigel Pharmaceuticals
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NCT05303519 Phase 3
Recruiting

SIGMA (Safusidenib in IDH1 Mutant Glioma Maintenance)

Enrollment
365 pts
Location
United States, Austr...
Sponsor
Nuvation Bio Inc.
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NCT05345002 Phase 2
Recruiting

All-Trans Retinoic Acid (ATRA) Plus PD-1 Inhibition in Recurrent IDH-Mutant Glioma

Enrollment
55 pts
Location
United States
Sponsor
Stephen Bagley, MD, MSCE
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NCT05355701 Phase 1
Recruiting

A Study to Learn About the Study Medicine Called PF-07799933 in People With Advanced Solid Tumors With BRAF Alterations.

Enrollment
267 pts
Location
United States, Canad...
Sponsor
Pfizer
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NCT06779487
Recruiting

Systemic Biomarkers to Predict Radiation-Induced Neurocognitive Decline

Enrollment
200 pts
Location
India
Sponsor
Tata Memorial Centre
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NCT07076498 Phase 1
Recruiting

Engineered HSV-1 M032 for the Treatment of Children and Adults With Newly Diagnosed Diffuse Midline Glioma After Standard of Care Radiation

Enrollment
20 pts
Location
United States
Sponsor
M.D. Anderson Cancer Center
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NCT06043765
Recruiting

Reducing Cognitive Impairment in Glioma with Repetitive Transcranial Magnetic Stimulation and Cognitive Strategy Training

Enrollment
16 pts
Location
Netherlands
Sponsor
Linda Douw
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NCT06156150
Recruiting

The Role of B7-H4 in Tumor Vaccine

Enrollment
160 pts
Location
China
Sponsor
Huashan Hospital
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NCT07286929
Recruiting

Evaluation of the Variation Over Time of Visuospatial Deficit in Patients With Parietal Lobe Glioma

Enrollment
40 pts
Location
Italy
Sponsor
Fondazione I.R.C.C.S. Istituto...
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NCT06650163 Phase 1
Recruiting

Zr-89 Crefmirlimab Berdoxam and Immuno-Positron Emission Tomography for the Imaging of Patients With Resectable Brain Tumors

Enrollment
20 pts
Location
United States
Sponsor
Jonsson Comprehensive Cancer C...
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NCT01772771
Recruiting

Molecular Testing for the MD Anderson Cancer Center Personalized Cancer Therapy Program

Enrollment
12,000 pts
Location
United States
Sponsor
M.D. Anderson Cancer Center
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NCT07413796
Recruiting

Comparison of Skin Closure Techniques in Oncological Neurosurgical Procedures: Intradermal Running Suture Versus Transdermal Interrupted Sutures

Enrollment
382 pts
Location
Poland
Sponsor
Medical University of Warsaw
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NCT06180434
Recruiting

Short Term Outcomes After PRoton and PhotoN RadiOtherapy for IDH Mutated Grade 2 and 3 Gliomas

Enrollment
320 pts
Location
Netherlands
Sponsor
Erasmus Medical Center
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NCT05188508 Phase 2
Recruiting

Pembrolizumab, Olaparib, and Temozolomide for People With Glioma

Enrollment
57 pts
Location
United States
Sponsor
Memorial Sloan Kettering Cance...
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NCT01906385 Phase 1, Phase 2
Recruiting

Maximum Tolerated Dose, Safety, and Efficacy of Rhenium Nanoliposomes in Recurrent Glioma (ReSPECT)

Enrollment
55 pts
Location
United States
Sponsor
Plus Therapeutics
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NCT03991832 Phase 2
Recruiting

Study of Olaparib and Durvalumab in IDH-Mutated Solid Tumors

Enrollment
58 pts
Location
Canada
Sponsor
University Health Network, Tor...
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NCT04047264
Recruiting

Feasibility of Intraoperative Microdialysis During Neurosurgery for Central Nervous System Malignancies

Enrollment
100 pts
Location
United States
Sponsor
Mayo Clinic
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NCT06496971 Phase 3
Recruiting

A Prospective Pivotal Study to Evaluate the Efficacy and Safety of Avastin® Bevacizumab (BEV) With or Without Microbubble-mediated Focused Ultrasound (FUS-MB) Using NaviFUS System in Recurrent Glioblastoma Multiforme Patients

Enrollment
32 pts
Location
Taiwan
Sponsor
NaviFUS Corporation
View Trial →
ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer  ·  Last Reviewed: April 2026  ·  Data Methodology