Acalabrutinib and Obinutuzumab for the Treatment of Chronic Lymphocytic Leukemia
Trial Parameters
Brief Summary
This phase II trial investigates the how well acalabrutinib and obinutuzumab work in treating patients with chronic lymphocytic leukemia (CLL). Acalabrutinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Immunotherapy with obinutuzumab may induce changes in body's immune system and may interfere with the ability of tumor cells to grow and spread. Giving acalabrutinib and obinutuzumab may help to control disease progression in CLL patients who have not received treatment for CLL.
Eligibility Criteria
Inclusion Criteria: * Diagnosis CLL/small lymphocytic lymphoma (SLL) and be untreated * Patients must have an indication for treatment by 2018 International Workshop on Chronic Lymphocytic Leukemia (IWCLL) Criteria * Eastern Cooperative Oncology Group (ECOG) performance status of 0-2 * Patients of childbearing potential must be willing to practice highly effective birth control during treatment and for 2 days after the last dose of acalabrutinib or 18 months after the last dose of obinutuzumab, whichever is later * A negative urine pregnancy test (within 7 days of day 1) is required for women with childbearing potential * Adequate renal and hepatic function as indicated by all of the following: Total bilirubin =\< 1.5 x institutional upper limit of normal (ULN) except for patients with bilirubin elevation due to Gilbert's disease who will be allowed to participate * An alanine transferase (ALT) =\< 2.5 x ULN * An estimated creatinine clearance (CrCl) of \> 30 mL/min, as calculated by t