A Mechanistic Study to Investigate tDCS and Working Memory in MCI Patients
Trial Parameters
Brief Summary
The current study is a mechanistic study to evaluate working memory gains from application of transcranial direct current stimulation (tDCS) in older adults with mild cognitive impairments (MCI) compared to cognitively healthy control
Eligibility Criteria
Inclusion Criteria * Age 60-95 years * Montreal Cognitive Assessment (MoCA) score 18 and above (scores will be adjusted for education) * Able to receive electrical stimulation * Ability to comprehend conversational voices * Adequate motor capacity to operate computer mouse and click-button in-scanner * Ability to participate in the intervention and attend training sessions Exclusion Criteria * Failure to provide informed consent * Contraindications to MRI recording (e.g., any kind of ferrous metallic stents or ferrous metal objects in the body, heart valve prosthesis, or other metal implants, claustrophobia, neurostimulation system, defibrillator, pacemaker, or other implanted device) * Left-handed, or left hand dominant * History of neurological, seizures, and psychiatric disorders, traumatic brain injury, incidence of stroke involving large vessel * Terminal illness with life expectancy less than 12 months, as determined by physician * Brain tumor or malformation or any foreign body