NCT06566586 A Clinical Study to Evaluate the Efficacy and Safety of TQB3702 Tablets Combined With Immunochemotherapy for the Treatment of B-cell Lymphoma
| NCT ID | NCT06566586 |
| Status | Recruiting |
| Phase | Phase 2 |
| Sponsor | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. |
| Condition | B-cell Lymphoma |
| Study Type | INTERVENTIONAL |
| Enrollment | 80 participants |
| Start Date | 2024-11-06 |
| Primary Completion | 2026-03 |
Eligibility & Interventions
Eligibility Fast-Check
Enter your details for a quick preliminary check. This does not replace medical advice.
What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
In Phase 2, researchers evaluate early signs of effectiveness. You may be randomized to receive the active treatment or a comparator. Monitoring continues closely.
This trial targets 80 participants in total. It began in 2024-11-06 with a primary completion date of 2026-03.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
To evaluate the efficacy and safety of TQB3702 tablets combined with immunochemotherapy for the treatment of B-cell lymphoma
Eligibility Criteria
Inclusion Criteria: * The subjects voluntarily joined the study, signed the informed consent, and the compliance was good; * Age: 18 years old ≤ age (when signing the informed consent) ≤75 years old; Eastern cooperative oncology group (ECOG) score: 0-2; Expected survival of more than 3 months; * Histologically confirmed B-cell lymphomas of the following types that meet the 2022 World Health Organization (WHO) diagnostic criteria: 1. Relapsed/refractory indolent B-cell lymphoma 2. Diffuse large B cell lymphoma（DLBCL） * Previous treatment: Relapsed/refractory inert B-cell lymphoma: have received at least one previous line of systemic standard therapy * Have at least one measurable lesion. * The main organs function well. * Female subjects of reproductive age should agree to use contraception (such as Iuds, contraceptives, or condoms) during the study period and for 6 months after the end of the study; Have a negative serum pregnancy test within 7 days prior to study enrollment and must be a non-lactating subject; Male subjects should agree to use avoidance during the study period and for 6 months after the end of the study period. Exclusion Criteria: * Have had or are currently suffering from other malignant tumors within 3 years prior to the first medication. * Known or suspected central nervous system (CNS) aggression. * Relapsed/refractory inert B-cell lymphoma: previous allogeneic hematopoietic stem cell transplantation, or autologous hematopoietic stem cell transplantation within 3 months before the first treatment; * Recurrent/refractory indolent B-cell lymphoma: toxic reactions that do not return to ≤ National Cancer Institute standard for common toxic reactions (NCI-CTC) AE Grade 1 due to any previous treatment, excluding hair loss and fatigue; * Have multiple factors that affect oral drug absorption (such as inability to swallow, chronic diarrhea, and intestinal obstruction); * Received major surgical treatment or significant traumatic injury within 28 days before the start of study treatment; * Hyperkinetic/venous thrombosis events occurred within 6 months before the first medication; * Have a history of psychotropic drug abuse and can not quit or have mental disorders; * Subjects with any severe and/or uncontrolled disease; * Received live vaccine or messenger ribonucleic acid (mRNA) vaccine within 4 weeks before the first dose, or planned to receive live vaccine or mRNA vaccine during the study; * Participated in clinical trials of other antitumor drugs within 4 weeks before the first medication; * Subjects who, in the judgment of the investigator, have concomitant diseases that seriously endanger the safety of the subjects or affect the completion of the study, or subjects who are not suitable for enrollment for other reasons.
Contact & Investigator
Frequently Asked Questions
Who can join the NCT06566586 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, up to 75 Years, studying B-cell Lymphoma. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
What phase is the NCT06566586 trial and what does that mean for participants?
Phase 2 trials evaluate whether the treatment shows signs of effectiveness while continuing to monitor safety. More participants are enrolled than in Phase 1 to help refine the treatment protocol.
Is NCT06566586 currently recruiting?
Yes, NCT06566586 is actively recruiting participants. Contact the research team at zengjunli@163.com for enrollment information.
Where is the NCT06566586 trial being conducted?
This trial is being conducted at Beijing, China, Lanzhou, China, Guangzhou, China, Guigang, China and 11 additional locations.
Who is sponsoring the NCT06566586 clinical trial?
NCT06566586 is sponsored by Chia Tai Tianqing Pharmaceutical Group Co., Ltd.. The trial plans to enroll 80 participants.