NCT07719075 5 Versus 10 mcg Norepinephrine Bolus in Treatment of Postinduction and Early Intraoperative Hypotension in Emergency Abdominal Surgery
| NCT ID | NCT07719075 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Cairo University |
| Condition | Hypotension on Induction |
| Study Type | INTERVENTIONAL |
| Enrollment | 136 participants |
| Start Date | 2026-08-04 |
| Primary Completion | 2026-12 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 136 participants in total. It began in 2026-08-04 with a primary completion date of 2026-12.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
Postinduction hypotension is a frequent intraoperative complication, particularly in emergency abdominal surgery due to factors such as sepsis, hypovolemia, and limited preoperative cardiac assessment. Because it can lead to serious organ injury, prompt prevention and management are essential. Vasopressors, including ephedrine, phenylephrine, and norepinephrine, are commonly used, with NE gaining interest as an intraoperative bolus despite uncertainty about the optimal dose in general surgery population The aim of this study is to compare 5 mcg to 10 mcg norepinephrine bolus for treatment of postinduction hypotension and early intraoperative in emergency abdominal surgery.
Eligibility Criteria
Inclusion Criteria: * Adult patients, American Society of anesthesiologists (ASA) I-III undergoing emergency abdominal surgery Exclusion Criteria: * Severe cardiac morbidities (impaired contractility with ejection fraction \< 45%, heart block, arrhythmias, tight valvular lesions) * Patients on vasopressor infusion, * Pregnant or lactating women, * Allergy of any of the study drugs
Contact & Investigator
Frequently Asked Questions
Who can join the NCT07719075 clinical trial?
This trial is open to participants of all sexes, aged 21 Years or older, up to 65 Years, studying Hypotension on Induction. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07719075 currently recruiting?
Yes, NCT07719075 is actively recruiting participants. Contact the research team at maha.mostafa@cu.edu.eg for enrollment information.
Where is the NCT07719075 trial being conducted?
This trial is being conducted at Cairo, Egypt.
Who is sponsoring the NCT07719075 clinical trial?
NCT07719075 is sponsored by Cairo University. The trial plans to enroll 136 participants.