🇺🇸 United States Country × Condition
major depressive disorder Clinical Trials in United States
Active clinical trials for major depressive disorder with research sites in United States. All data sourced live from ClinicalTrials.gov — updated daily.
Active Trials: 21 // Recruiting: 21 Phases: Phase 2, Phase 3 // Updated: Daily
Total Trials
21
Recruiting Now
21
Country
🇺🇸 United States
Active Trials in United States (21)
NCT00018057 Phase 2
Recruiting
Study of Neuro-Cognitive Correlates of Pediatric Anxiety Disorders
Enrollment
3,500 pts
Country
🇺🇸 United States
National Institute of Mental Health...
View Trial → NCT06938841
Recruiting
Maintenance rTMS for Depression (Maitr-De)
Enrollment
75 pts
Country
🇺🇸 United States
University of California, San Diego
View Trial → NCT06700902
Recruiting
Taking Action for College Students
Enrollment
300 pts
Country
🇺🇸 United States
Temple University
View Trial → NCT07003997 Phase 2
Recruiting
JAK Signaling in Depression
Enrollment
100 pts
Country
🇺🇸 United States
Emory University
View Trial → NCT05366270
Recruiting
Peripheral Neuroimmune Mechanisms of Hyperthermia
Enrollment
60 pts
Country
🇺🇸 United States
Massachusetts General Hospital
View Trial → NCT04788524
Recruiting
Neural Correlates of Stress and Perceived Control in Adolescent Depression
Enrollment
80 pts
Country
🇺🇸 United States
Mclean Hospital
View Trial → NCT06966401 Phase 3
Recruiting
Long-Term Study to Assess the Safety and Tolerability of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)
Enrollment
850 pts
Country
🇺🇸 United States
Neurocrine Biosciences
View Trial → NCT05996900
Recruiting
Investigating the Neural Mechanisms of Repetitive Brain Stimulation With Invasive and Noninvasive Electrophysiology in Humans
Enrollment
49 pts
Country
🇺🇸 United States
Stanford University
View Trial → NCT06402955 Phase 2
Recruiting
Imaging Depression in Parkinson's Disease
Enrollment
120 pts
Country
🇺🇸 United States
Yale University
View Trial → NCT03065335 Phase 1
Recruiting
Neuropharmacologic Imaging and Biomarker Assessments of Response to Acute and Repeated-Dosed Ketamine Infusions in Major Depressive Disorder
Enrollment
150 pts
Country
🇺🇸 United States
National Institute of Mental Health...
View Trial → NCT05773755
Recruiting
DBS for TRD With the Medtronic Percept PC
Enrollment
20 pts
Country
🇺🇸 United States
Helen Mayberg, MD
View Trial → NCT07105111 Phase 4
Recruiting
A Study to Evaluate the Effectiveness of Valbenazine in Adult Participants With Tardive Dyskinesia (TD) Who Remain Symptomatic While Receiving or After Stopping a Vesicular Monoamine Transporter 2 (VMAT2) Inhibitor
Enrollment
50 pts
Country
🇺🇸 United States
Neurocrine Biosciences
View Trial → NCT04004169
Recruiting
Closed-Loop Deep Brain Stimulation for Major Depression
Enrollment
12 pts
Country
🇺🇸 United States
Andrew Krystal
View Trial → NCT06213324 Phase 4
Recruiting
Neural Circuit Effects of Ketamine in Depression
Enrollment
120 pts
Country
🇺🇸 United States
Icahn School of Medicine at Mount S...
View Trial → NCT06462196
Recruiting
Natural History of Depression, Bipolar Disorder and Suicide Risk
Enrollment
500 pts
Country
🇺🇸 United States
National Institute of Mental Health...
View Trial → NCT06529029 Phase 2, Phase 3
Recruiting
Low Amplitude Pulse Seizure Therapy Versus Standard Ultra-Brief Right Unilateral Electroconvulsive Therapy
Enrollment
30 pts
Country
🇺🇸 United States
Michigan State University
View Trial → NCT05194098
Recruiting
Using Electrophysiology to Index Non-invasive Brain Stimulation Effects on Reward System Functioning in Depression
Enrollment
45 pts
Country
🇺🇸 United States
San Francisco Veterans Affairs Medi...
View Trial → NCT05538910
Recruiting
Defining Neurobiological Links Between Substance Use and Mental Illness
Enrollment
620 pts
Country
🇺🇸 United States
National Institute on Drug Abuse (N...
View Trial → NCT07507370
Recruiting
CARED : A Novel Rapid Treatment Paradigm for Depression
Enrollment
30 pts
Country
🇺🇸 United States
University of North Carolina, Chape...
View Trial → NCT06132581
Recruiting
Causal Role of Delta-beta Coupling for Goal-directed Behavior in Anhedonic Depression
Enrollment
72 pts
Country
🇺🇸 United States
Florida State University
View Trial → NCT05570812 Phase 2
Recruiting
Neuroactive Steroid to Treat Depressed Mood: A Trial for People With HIV
Enrollment
120 pts
Country
🇺🇸 United States
Massachusetts General Hospital
View Trial → Frequently Asked Questions
How many major depressive disorder clinical trials are active in United States?
There are currently 21 active clinical trials for major depressive disorder with sites in United States, of which 21 are actively recruiting patients.
How can I join a major depressive disorder clinical trial in United States?
To join a major depressive disorder clinical trial in United States, select a recruiting trial below and check the eligibility criteria. Contact the trial's principal investigator or the listed site in United States directly. All trials listed here are sourced from ClinicalTrials.gov, the official U.S. registry of clinical studies.
What phases are major depressive disorder trials in United States?
Active major depressive disorder trials in United States span Phase 2, Phase 3, Phase 1, Phase 4, Phase 2, Phase 3. Phase I trials test safety, Phase II test efficacy, and Phase III compare against standard treatments in larger patient populations.
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