NCT05996900 Investigating the Neural Mechanisms of Repetitive Brain Stimulation With Invasive and Noninvasive Electrophysiology in Humans
| NCT ID | NCT05996900 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Stanford University |
| Condition | Major Depressive Disorder |
| Study Type | INTERVENTIONAL |
| Enrollment | 49 participants |
| Start Date | 2023-09-01 |
| Primary Completion | 2027-10-01 |
Eligibility & Interventions
Eligibility Fast-Check
Enter your details for a quick preliminary check. This does not replace medical advice.
What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 49 participants in total. It began in 2023-09-01 with a primary completion date of 2027-10-01.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
Transcranial magnetic stimulation (TMS) is an effective treatment for depression, but clinical outcome is suboptimal, partially because investigators are missing biologically-grounded brain markers which show that TMS is modifying activity at the intended target in the brain. The goal of this proposal is to characterize the key markers of the brain's response to repeated doses of TMS with high resolution using invasive brain recordings in humans, and relate these brain markers to noninvasive recordings. These markers will improve the understanding of TMS and can be used to optimize and enhance clinical efficacy for depression and other psychiatric disorders.
Eligibility Criteria
Inclusion Criteria: * Men and women, ages 18 to 65 * Medication-refractory epilepsy requiring phase II monitoring * Must have intellectual capacity to ensure adequate comprehension of the study and potential risks involved in order to provide informed consent * No current or history of major neurological disorders other than epilepsy Exclusion Criteria: * Those with a contraindication for MRIs (e.g. implanted metal) * Any unstable medical condition * Neurological or uncontrolled medical disease * Active substance abuse * Currently pregnant or breastfeeding
Contact & Investigator
Frequently Asked Questions
Who can join the NCT05996900 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, up to 65 Years, studying Major Depressive Disorder. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT05996900 currently recruiting?
Yes, NCT05996900 is actively recruiting participants. Contact the research team at kellerlab@stanford.edu for enrollment information.
Where is the NCT05996900 trial being conducted?
This trial is being conducted at Stanford, United States.
Who is sponsoring the NCT05996900 clinical trial?
NCT05996900 is sponsored by Stanford University. The trial plans to enroll 49 participants.