To join a chronic pain clinical trial in United States, select a recruiting trial below and check the eligibility criteria. Contact the trial's principal investigator or the listed site in United States directly. All trials listed here are sourced from ClinicalTrials.gov, the official U.S. registry of clinical studies.

What phases are chronic pain trials in United States?

Active chronic pain trials in United States span Phase 3, Phase 1. Phase I trials test safety, Phase II test efficacy, and Phase III compare against standard treatments in larger patient populations.

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ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer · Last Reviewed: November 2026 · Data Methodology

Active Trials in United States (25)

Novel Stimulation Patterns to Improve the Effectiveness of Spinal Cord Stimulation

The PROACTIVE Study for Black Elders

Noninvasive Brain Stimulation for Treating Carpal Tunnel Syndrome

Optimizing Chronic Pain Care With Mindfulness and Chronic Pain Management Visits

POP SINGER Randomized Clinical Trial

Our Whole Lives Gemini: Virtual Integrative Medical Group Visits for Managing Chronic Pain

Brief Mindfulness-Oriented Recovery Enhancement vs Brief Cognitive-Behavioral Therapy for Chronic Pain

A Community Health Worker-Led Program for Chronic Pain and Loneliness in Older Adults

Mechanisms of Mindfulness Meditation and Self-Hypnosis for Pain in Older Adults With Chronic Pain

Individual Differences in Gait and Osteoarthritis Pain

Post Market Evaluation of Real World Outcomes and Durability to Support Implantable Inceptiv™ Spinal Cord Stimulation Therapy

Prospective Assessment of Integrative Therapies for Neuromusculoskeletal Pain (PAIN)

Healthy Behaviors for Insomnia Prevention in People With HIV and Ongoing Pain

CIH Stepped Care for Co-occurring Chronic Pain and PTSD

Long-Term Real-World Outcomes Study on Patients Implanted With a Neurostimulator

The Teaspoon Study - Telefitting Spinal Cord Stimulation for Pain

Reducing Chronic Pain Following Cesarean Delivery

Optimization of NIBS for Treatment of Addiction

Interoceptive Awareness and Function in Adolescents With Chronic Pain

Improving Spinal Cord Stimulation With ECAPS

Novel Cellular Therapy for the Treatment of Pain Associated With Chronic Pancreatitis

RCT of a Weighted Blanket to Reduce Pain in Veterans With Chronic Pain

Integrated PTSD and Chronic Pain Treatment

Scrambler Therapy in Chronic Pancreatitis

VCOM Pain Free Research Collaborative

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