To join a breast cancer clinical trial in United States, select a recruiting trial below and check the eligibility criteria. Contact the trial's principal investigator or the listed site in United States directly. All trials listed here are sourced from ClinicalTrials.gov, the official U.S. registry of clinical studies.

What phases are breast cancer trials in United States?

Active breast cancer trials in United States span Phase 1, EARLY_Phase 1, Phase 2, Phase 3, Phase 1, Phase 2, Phase 2, Phase 3, Phase 4. Phase I trials test safety, Phase II test efficacy, and Phase III compare against standard treatments in larger patient populations.

Browse More

All United States Trials → Global breast cancer Trials → All Countries → All Trials →

ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer · Last Reviewed: September 2026 · Data Methodology

Active Trials in United States (73)

HER2 Vaccine for Locally Advanced Breast Cancer

Study to Evaluate Biomarkers and Safety of Dapagliflozin Concomitant With Neoadjuvant Therapy

A Study of a Side Effects and Resource Navigation Program for People With Cancer

Cardiometabolic Screening Program

Feasibility and Acceptibility of a Multi-site Trial of Time Restircted Eating During Chemotheraply for Breast Cancer.

Window Study of Intratumoral Mitazalimab in Breast Cancer (WINIT-BC)

Breast Elasticity Imaging During Neoadjuvant Chemotherapy

IMPACT Trial: Intervention to iMProve AdherenCe Equitably

Study to Evaluate the Feasibility of Twice Daily Use of Topical Azelaic Acid in Breast Cancer Patients Undergoing Radiation

MATCH-UP: MAking Telehealth-Delivery of Cancer Care at Home Effective and Safe-Upscaled: A Pragmatic Cluster Randomized Trial

Impact of Intermittent Fasting on Biomarkers of Inflammation and Health-Related Quality of Life: A Feasibility Trial for Women With HR+/HER2- Early Breast Cancer

Tirzepatide Weight Loss for MRD+ Early Breast Cancer

Axelopran for Advanced Cancer in Patients Receiving Opioids

FIH Study of RGT-419B Alone and With Endocrine Therapy in HR-Positive, HER2-Negative Advanced/Metastatic Breast Cancer

Susan G. Komen's ShareForCures

Molecular Residual Disease Assessment in a Representative Diverse Population of Patients With Early-stage Breast Cancer

[18F] F-GLN by PET/CT in Breast Cancer

A Study of NT-175 in Adult Participants With Advanced Malignancies That Are Positive for HLA-A*02:01 and the TP53 R175H Mutation

Phase 3 Study to Evaluate the Efficacy and Safety of HER2/Neu Peptide GLSI-100 (GP2 + GM-CSF) in HER2/Neu Positive Subjects

Dissemination of BREASTChoice AIM1-B

A Study of a Comprehensive Prevention Program to Reduce Lymphedema After Axillary Lymph Node Dissection in People With Breast Cancer

A Study of a One-Time Counseling Session to Help Reduce Depression, Anxiety, and Distress in People With Breast Cancer

Identification of Breast Cancer in Breath Samples Using Trained Detection Dogs

Desloratadine to Prevent Taxane-induced Peripheral Neuropathy in Patients With Breast Cancer

FES BPET-DBT in Newly Diagnosed Breast Cancer

Improving Genetic Counseling for BRCA+ Mothers

Trial of Therapies With IT cDC1s Combined w/ IT Trastuzamab for Her+ or IT Nivolumab for Her- BC LMD

The MOMENTUM Study: The Multiple Outcome Evaluation of Radiation Therapy Using the MR-Linac Study

Repeat Breast Conserving Surgery Followed by Daily Partial Breast Irradiation in Ipsilateral Breast

Circulating Tumor DNA (ctDNA) for Early Treatment Response Assessment of Solid Tumors

Evaluate BL-B01D1 in Patients With Metastatic or Unresectable Non-Small Cell Lung Cancer (NSCLC) and Other Solid Tumors

Anastrazole, Fulvestrant & Abemaciclib for HR+HER2- Metastatic Breast Cancer

PROGRESS: Precision Oncology Using Genomic Reflexive Evaluations for Study Selection and Survival

A Study of MGC026 in Participants With Advanced Solid Tumors

Memantine and Exercise to Improve Cognitive Function and Modulate Biological Pathways of Cognitive Decline During Chemotherapy in Breast Cancer

Real-Time Assessment Of Breast Cancer Lumpectomy Specimen Margins With Nonlinear Microscopy

Axillary Radiotherapy or Axillary Lymph Node Dissection in Patients With Clinically Node- Positive Breast Cancer Undergoing Upfront Tailored Axillary Surgery

Exercise Oncology Clinic Pilot Feasibility Trial

Connecting Black Families in Houston, Texas to Hereditary Cancer Genetic Counseling, Genetic Testing, and Cascade Testing by Using a Simple Genetic Risk Screening Tool and Telegenetics

A Study of Emiltatug Ledadotin (Emi-Le) in Participants With Solid Tumors

Atezolizumab Plus Tivozanib in Immunologically Cold Tumor Types

Testing a Mammography Decision Intervention in a Rural Setting

Multi-center MRD Registry for Inflammatory Breast Cancer

Delayed Sentinel Lymph Node Biopsy in Ductal Cancer in Situ

A Phase II Study Evaluating the Efficacy and Safety of Inavolisib Plus Ribociclib Plus Fulvestrant Versus Placebo Plus Ribociclib Plus Fulvestrant in Participants With Advanced Breast Cancer

Development of Patient Derived Xenografts (PDX) in Patients With Breast Cancer

Phase I Study of SYS6043 in Patients With Advanced/Metastatic Solid Tumors

A Synthetic Lethality-Focused Algorithm to Identify Therapeutic Options in Advanced Metastatic Breast Cancer (SYNTHESIS-Breast)

Refining Local-Regional Therapy for IBC

A Phase 2 Study of PCS6422 With Capecitabine in Patients With Advanced or Metastatic Breast Cancer

High Risk Breast Clinic: Protocol for Women at Increased Risk for Developing Breast Cancer

Repurposing Riluzole for Cancer-Related Cognitive Impairment: A Pilot Trial

Genetic & Pathological Studies of BRCA1/BRCA2: Associated Tumors & Blood Samples

IDOV-Immune for Advanced Solid Tumors

NearWave Optical Molecular Monitoring

A Study to Learn About the Study Medicine Called PF-07248144 in Combination With Fulvestrant in People With HR-positive, HER2-negative Advanced or Metastatic Breast Cancer Who Progressed After a Prior Line of Treatment.

Tart Cherry Juice as a Dietary Supplement for the Prevention of Paclitaxel-Induced Neuropathy

First-in-Human Study of Tersolisib (STX-478) as Monotherapy and in Combination With Other Antineoplastic Agents in Participants With Advanced Solid Tumors

Converting HR+ Breast Cancer Into an Individualized Vaccine

ATEMPT 2.0: Adjuvant T-DM1 vs TH

TMEM-MRI: A Pilot Feasibility Study of MRI for Imaging of TMEM in Patients With Operable Breast Cancer

Study of RGT-490 in Patients With PIK3CA-Mutated Advanced Solid Tumors

Bortezomib Followed by Pembrolizumab and Cisplatin in metTNBC

Adjuvant Chemoradiation and Biomarkers of Response in High-risk Breast Cancer

FT836 With or Without Chemotherapy and/or Monoclonal Antibodies, in Participants With Advanced Solid Tumors

Pilot SMART of a Remotely Delivered, Physical Activity Intervention for Breast Cancer Survivors

Time-Restricted Eating and Cancer: Clinical Outcomes, Mechanisms, and Moderators

Exploring the Feasibility of an Exercise and Noninvasive Brain Stimulation Intervention in Breast Cancer Survivors

A Phase 2 Study of Zanidatamab in Patients With HER2-expressing Tumors

GammaPod Dose Escalation Radiation for Early Stage Breast Cancer

Brain [18F]-FES PET/CT in Patients With Estrogen-Receptor Positive Breast Cancer

Evaluating the Use of a Medication 'Switch' vs Guideline-directed Interventions for Relieving Side Effects of Aromatase Inhibitors Among Breast Cancer Patients

Phase 1/2 Dose Finding, Safety and PK Study in Advanced Refractory Solid Tumors

Frequently Asked Questions