To join a breast cancer clinical trial in United States, select a recruiting trial below and check the eligibility criteria. Contact the trial's principal investigator or the listed site in United States directly. All trials listed here are sourced from ClinicalTrials.gov, the official U.S. registry of clinical studies.

What phases are breast cancer trials in United States?

Active breast cancer trials in United States span Phase 2, Phase 1, Phase 1, Phase 2, Phase 3, Phase 4. Phase I trials test safety, Phase II test efficacy, and Phase III compare against standard treatments in larger patient populations.

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Active Trials in United States (58)

Trial of Neratinib Plus Capecitabine in Subjects With HER2-Negative Metastatic Breast Cancer With Brain Metastases and Abnormally Active HER2 Signaling

BostonGene and Exigent Genomic INsight Study

A Study of PARG Inhibitor IDE161 in Participants With Advanced Solid Tumors

Exercise in Metastatic Breast Cancer: EMBody

Portable Scalp Cooling System (PSCS) to Prevent Hair Loss for Breast Cancer Patients (Cooler Heads)

A Study to Learn About Study Medicine ALTA2618 in Adults With AKT1 E17K-Mutant Solid Tumors

Safe and Explainable AI

A Study of an Alternative Treatment Approach (Preoperative Radiotherapy, Then Mastectomy, Then Immediate Reconstruction Surgery) in People With T4 Breast Cancer

Real-Time Assessment Of Breast Cancer Lumpectomy Specimen Margins With Nonlinear Microscopy

Comprehensive Outcomes for After Cancer Health

Magseed Enabled Long-Term Localization of Axillary Lymph Nodes

Virtual Mindful After Cancer (MAC) Intervention to Promote Sexual Health for Breast and Gynecologic Cancer Survivors

Study of Zelenectide Pevedotin in Participants With Advanced Breast Cancer

A Study of PARG Inhibitor ETX-19477 in Patients With Advanced Solid Malignancies

A Phase 2 Study of PCS6422 With Capecitabine in Patients With Advanced or Metastatic Breast Cancer

FT836 With or Without Chemotherapy and/or Monoclonal Antibodies, in Participants With Advanced Solid Tumors

Dissemination of BREASTChoice AIM1-B

Tucatinib+Trastuzumab+Eribulin in HER2+ MBC

WashU DIEP Flap Video and Patient Understanding Improvement

Locally AblatiVe TherApy in OLigO-pRogressive SOlid TUmorS (VALOROUS)

Sacituzumab Govitecan +/- Pembrolizumab in Metastatic TNBC

Building on Trust: Navigating Preventive Lung, Breast, and Prostate Cancer Screenings at Community Resource Spots

Conventionally Fractionated vs. Hypofractionated Comprehensive Nodal Irradiation for Breast Cancer Using Pencil Beam Scanning Proton Therapy

A Study to Evaluate Safety, Tolerability and Preliminary Activity of AGX101 in Participants With Advanced Solid Tumors

A Study of Dato-DXd in Inoperable or Metastatic Hormone Receptor-positive, HER2 IHC 0 Breast Cancer

A Study of Antibiotic Delivery to Prevent Infection After Breast Tissue Expander Placement

High-Resolution Lower Dose Dedicated Breast Computed Tomography (CT)

Converting HR+ Breast Cancer Into an Individualized Vaccine

EXploring Inflammation and Social deTerminants Study in Breast Cancer Patients

Lymphedema Surveillance Study

COOL-IT-PRO: Cryoablation of Breast Cancer in Non-surgical Patients

Phase II Protocol of Proton Therapy for Partial Breast Irradiation in Early Stage Breast Cancer

Testing a Mammography Decision Intervention in a Rural Setting

Study of Stereotactic Radiosurgery With Olaparib Followed by Durvalumab and Physician's Choice Systemic Therapy in Subjects With Breast Cancer Brain Metastases

A Pilot Study to Assess the Clinical Utility of PYLARIFY PET-CT for Detecting Metastasis in Pancreatic Cancer, Hepatocellular Carcinoma and Breast Cancer

Endocrine Treatment Alone for Elderly Patients With Estrogen Receptor Positive Operable Breast Cancer and Low Recurrence Score

F-Tryptophan PET/CT in Human Cancers

Repurposing Riluzole for Cancer-Related Cognitive Impairment: A Pilot Trial

PAS 1ml Magtrace® for Sentinel Lymph Node Biopsy in Breast Cancer Patients

Evaluating an Evidence-Based Family History Screening Program Adapted to Increase Reach and Uptake of Screening for BRCA-Associated Cancers in Rural Public Health Clinics

Biomarkers to Detect Endocrine Therapy Resistance

Triple Negative Breast Cancer and Germline Hereditary Breast and Ovarian Cancer Mutation Carrier Registry

A Study of the Impact of Endocrine Therapy on Surgical Outcomes in People With Breast Cancer

Trial of Pre-operative Neratinib and Endocrine Therapy With Trastuzumab in ER-Positive, HER-2 Positive Breast Cancers

Compare Adjuvant Monotherapy With Endocrine or Accelerated Partial Breast Irradiation After Lumpectomy

Evaluating Digital Micro-Interventions to Reduce Distress and Increase Wellbeing in Breast Cancer Survivors

Tirzepatide Weight Loss for MRD+ Early Breast Cancer

ERAS Protocols in Breast Conserving Surgery

Study of 3-Day Partial Breast Radiation Therapy in Women With Breast Cancer

The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE)

Resistance and Aerobic Exercise for Prevention in Women With Dense Breasts (REP-D)

Gene Modified Immune Cells After Conditioning Regimen for the Treatment of Stage IIIC or IV Melanoma or Metastatic Solid Tumors

Study of 18F-FFNP Breast PET/MRI

Real-Time MRI-Guided 3-Fraction Accelerated Partial Breast Irradiation in Early Breast Cancer

Improving Care for Rural Patients With Solid Tumors

The Florida ASCENT Study

Community-led Navigation to Address Disparities in Mammography Among Native American Women

Partial Breast Re-irradiation Using Ultra Hypofractionation (PRESERVE)

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