To join a breast cancer clinical trial in United States, select a recruiting trial below and check the eligibility criteria. Contact the trial's principal investigator or the listed site in United States directly. All trials listed here are sourced from ClinicalTrials.gov, the official U.S. registry of clinical studies.

What phases are breast cancer trials in United States?

Active breast cancer trials in United States span Phase 2, Phase 1, Phase 1, Phase 2, Phase 3, EARLY_Phase 1, Phase 4, Phase 2, Phase 3. Phase I trials test safety, Phase II test efficacy, and Phase III compare against standard treatments in larger patient populations.

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ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer · Last Reviewed: November 2026 · Data Methodology

Active Trials in United States (62)

PAS 1ml Magtrace® for Sentinel Lymph Node Biopsy in Breast Cancer Patients

Navigation Interventions for Patients With Breast Cancer and High-risk Social Determinants of Health

Trial of Therapies With IT cDC1s Combined w/ IT Trastuzamab for Her+ or IT Nivolumab for Her- BC LMD

Study to Evaluate the Feasibility of Twice Daily Use of Topical Azelaic Acid in Breast Cancer Patients Undergoing Radiation

HER2 FPBMC in Patients With Metastatic Breast and Prostate Cancer (AM006)

Administration of Autologous T-Cells Genetically Engineered to Express T-Cell Receptors Reactive Against Neoantigens in People With Metastatic Cancer

Palazestrant in Combination With Ribociclib for the First-line Treatment of ER+/HER2- Advanced Breast Cancer

Building on Trust: Navigating Preventive Lung, Breast, and Prostate Cancer Screenings at Community Resource Spots

PhII Randomized CAPecitabine + ELAcestrant vs. Capecitabine Alone in ER+ Breast Cancer (CAPELA)

Atezolizumab + Sacituzumab Govitecan to Prevent Recurrence in TNBC (ASPRIA)

Navigator-Assisted Hypofractionation (NAVAH) on Radiation Therapy Completion in Breast Cancer and Prostate Cancer

Comparison of Breast Cancer Screening With CESM to DBT in Women With Dense Breasts

Neuromodulation of Cardiovascular Risks Associated With Cardiotoxic Chemotherapy

Atezolizumab Plus Tivozanib in Immunologically Cold Tumor Types

Near Infrared Spectroscopy (NIRS) as a Method for Measuring Oxidative Capacity of Skeletal Muscle Mitochondria in Breast Cancer and All Gynecological Cancer Patients

5 vs. 9-day Course of Whole Breast Radiotherapy With Boost for Early-stage Breast Cancer

Utility of a Mobile Application for Young Women With Breast Cancer

Pharmacologic Therapies to Mitigate Radiation- Associated Heart Disease

Core Biopsies for Establishing a Breast Tumor Tissue Repository

A Study to Evaluate Safety, Tolerability and Preliminary Activity of AGX101 in Participants With Advanced Solid Tumors

ERAS Protocols in Breast Conserving Surgery

Study of 18F-FFNP Breast PET/MRI

A Study Evaluating the Feasibility and Compliance of Manual Lymphatic Drainage Comparing Indocyanine-Green (ICG) Guided vs. Traditional Guided in Patients Undergoing Axillary Node Dissection for the Treatment of Breast Cancer

A Phase I/IIa Study of AZD8205 Given Alone or Combined, in Participants With Advanced/Metastatic Solid Malignancies

Identifying Patterns in the Breath of Individuals With Breast Cancer

Personalized Second Chance Breast Conservation (PSCBC): A Prospective Phase II Clinical Study

Individuals on Hormone Therapy Breast Cancer Screening Pilot

The Florida ASCENT Study

A Randomized Two-Arm Proof of Concept Study Testing A Novel Approach to Exercise Promotion Based on Affect-regulation

Study to Assess the Ability of the Portable Scalp Cooling System (PSCS) to Prevent Hair Loss

A Study of Abemaciclib and Radiation Therapy in People With Metastatic Breast Cancer

Evolutionary Clinical Trial for Novel Biomarker-Driven Therapies

Fecal Microbiota Transplantation in Treating Immune-Checkpoint Inhibitor Induced-Diarrhea or Colitis in Genitourinary Cancer Patients

The MOMENTUM Study: The Multiple Outcome Evaluation of Radiation Therapy Using the MR-Linac Study

A Phase 1 Study of IM-1617 in Participants With Advanced Cancer

Empowering Vulnerable and Resilient Latinas to Obtain Breast Cancer Care

SAVE Trial: SAfe Opioid Use Video Education

Two Versus One Week Breast Radiotherapy (RT)

A Formative Evaluation For Improving Breast Cancer Hormone Receptor Testing in Tanzania

A Study of a Comprehensive Prevention Program to Reduce Lymphedema After Axillary Lymph Node Dissection in People With Breast Cancer

Abemaciclib Dose Escalation to Maintain Intensity (ADE-MI)

Factors Associated With Breast Cancer Risks and Outcomes

A Study of Changes in Ki67 Expression in People With Breast Cancer Receiving Endocrine Therapy Before Surgery

Pharmacokinetics and Safety of Epidiferphane and Taxanes in Breast Cancer Patients

A Study of Pembrolizumab and Ablation (Cryoablation or Histotripsy) in People With Breast Cancer

Intensity Modulated Radiotherapy (IMRT) vs. 3D-conformal Accelerated Partial Breast Irradiation (APBI) for Early Stage Breast Cancer After Lumpectomy

EXActDNA-003 / NSABP B-64: Study of Molecular Residual Disease Detection in Breast Cancer (MRD)

Axelopran for Advanced Cancer in Patients Receiving Opioids

Talking to Employers and Medical Staff About Breast Cancer Treatment and Your Job

Promoting Resilience in Women With Breast Cancer (PRISM -MBC)

Connecting Black Families in Houston, Texas to Hereditary Cancer Genetic Counseling, Genetic Testing, and Cascade Testing by Using a Simple Genetic Risk Screening Tool and Telegenetics

Liposomal Bupivacaine Vs Bupivacaine with Dexmedetomidine in Erector Spinae Plane Blocks for Mastectomies

FES BPET-DBT in Newly Diagnosed Breast Cancer

ASHBY: Accelerated Super-Hypofractionated Breast Brachytherapy

Study of RGT-490 in Patients With PIK3CA-Mutated Advanced Solid Tumors

Positron Emission Tomography (PET) Imaging With Zirconium-89 (89Zr)-Trastuzumab for Prediction of HER2 Targeted Therapy Effectiveness

MATCH-UP: MAking Telehealth-Delivery of Cancer Care at Home Effective and Safe-Upscaled: A Pragmatic Cluster Randomized Trial

A Study of Skipping Radiation Therapy in People With Breast Cancer

Generation of Heart Muscle Cells From Blood or Skin Cells of Breast Cancer Patients

Adjuvant Chemoradiation and Biomarkers of Response in High-risk Breast Cancer

Conventionally Fractionated vs. Hypofractionated Comprehensive Nodal Irradiation for Breast Cancer Using Pencil Beam Scanning Proton Therapy

Reiki Breast Surgery QOL Project for Women Undergoing Breast Surgery

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