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Medical Condition
severe asthma
Total Trials
6
Recruiting Now
6
Trial Phases
Phase 3
Asthma clinical trials are increasingly stratified by phenotype β€” Type 2 high (eosinophilic, IgE-mediated) versus Type 2 low (neutrophilic or paucigranulocytic) β€” because this distinction predicts response to biologic therapies. The anti-IL-5, anti-IL-4/13, and anti-TSLP antibody classes have revolutionized severe asthma management, and trials now aim to achieve full remission rather than just symptom control.
Trials evaluate dupilumab combinations, tezepelumab (anti-TSLP) in Type 2 low asthma, itepekimab, biologic step-down strategies, and oral corticosteroid-sparing approaches. Digital inhalers with adherence monitoring are being validated as outcomes tools. Bronchial thermoplasty for severe non-biologic-responsive patients remains an active surgical comparator.
Frequently Asked Questions — severe asthma Clinical Trials
How many clinical trials are currently recruiting for severe asthma?
ClinicalMetric currently tracks 6 actively recruiting clinical trials for severe asthma, sourced in real time from ClinicalTrials.gov. The total number of registered studies—including those not yet enrolling or in active follow-up—is 6. Trial availability changes daily as new studies open enrollment and existing ones reach capacity.
What trial phases are available for severe asthma?
severe asthma research spans Phase 3 (1 trial). Phase 1 studies evaluate safety and dosing in small groups, Phase 2 studies assess preliminary efficacy in 100–300 participants, and Phase 3 trials compare the new treatment against the standard of care in 300–3,000+ patients. Phase 4 post-approval studies monitor long-term outcomes in real-world populations.
How do I find out if I qualify for a severe asthma clinical trial?
Eligibility criteria for severe asthma trials vary by study and typically specify age range, disease stage or severity, prior treatment history, and specific diagnostic or laboratory parameters. Each listing on ClinicalMetric links to the full protocol on ClinicalTrials.gov, where inclusion and exclusion criteria are documented. Contact the sponsoring site's research coordinator directly to confirm your eligibility—your treating physician or specialist can also help identify the most appropriate trial based on your medical history and current treatment status.
Trial Phases
Phase 3 1
Top Sponsors
1 trial
1 trial
1 trial
1 trial
1 trial
Recruiting Clinical Trials
NCT07328035
Recruiting
Remission in Adults With Severe Asthma in Thailand
Enrollment
230 pts
Location
Thailand
Sponsor
Thammasat University
NCT04334031
Recruiting
Deployment o the Multidisciplinary Prospective Cohort Imminent
Enrollment
2,200 pts
Location
France
Sponsor
University Hospital, Lille
NCT07292805
Recruiting
Bronchial Thermoplasty for Adults With Severe Asthma in the Biologic Era
Enrollment
90 pts
Location
Netherlands
Sponsor
Academisch Medisch Centrum - U...
NCT07530770
Recruiting
Real-World Effectiveness of Benralizumab in Allergic Bronchopulmonary Aspergillosis
Enrollment
20 pts
Location
China
Sponsor
Qianfoshan Hospital
NCT07363642 Phase 3
Recruiting
Phase 3b Study in Patients With Severe Asthma Treated With Tezepelumab
Enrollment
400 pts
Location
China
Sponsor
AstraZeneca
NCT06625216
Recruiting
Severe Asthma Network Italy
Enrollment
5,000 pts
Location
Italy
Sponsor
Società Italiana di Allergolog...
ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer · Last Reviewed: April 2026 · Data Methodology