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chronic pain syndrome

Total Trials
2
Recruiting Now
2
Trial Phases
Various

Chronic pain research has gained urgency given the limitations of opioid therapy and the search for non-addictive alternatives. Nav1.7 and Nav1.8 sodium channel blockers, CGRP antagonists (extended from migraine to other pain conditions), and neuromodulation approaches represent the most active mechanistic targets in current trials.

Trials investigate suzetrigine (Nav1.8 blocker), ziconotide intrathecal delivery, spinal cord stimulation with novel waveforms (burst, high-frequency), ketamine infusion protocols, low-dose naltrexone, and psychedelic-assisted pain management. Digital pain measurement tools and PROMIS scales are increasingly validated as primary endpoints.

Frequently Asked Questions — chronic pain syndrome Clinical Trials

How many clinical trials are currently recruiting for chronic pain syndrome?
ClinicalMetric currently tracks 2 actively recruiting clinical trials for chronic pain syndrome, sourced in real time from ClinicalTrials.gov. The total number of registered studies—including those not yet enrolling or in active follow-up—is 2. Trial availability changes daily as new studies open enrollment and existing ones reach capacity.
What trial phases are available for chronic pain syndrome?
chronic pain syndrome research spans multiple clinical trial phases. Phase 1 studies evaluate safety and dosing in small groups, Phase 2 studies assess preliminary efficacy in 100–300 participants, and Phase 3 trials compare the new treatment against the standard of care in 300–3,000+ patients. Phase 4 post-approval studies monitor long-term outcomes in real-world populations.
How do I find out if I qualify for a chronic pain syndrome clinical trial?
Eligibility criteria for chronic pain syndrome trials vary by study and typically specify age range, disease stage or severity, prior treatment history, and specific diagnostic or laboratory parameters. Each listing on ClinicalMetric links to the full protocol on ClinicalTrials.gov, where inclusion and exclusion criteria are documented. Contact the sponsoring site's research coordinator directly to confirm your eligibility—your treating physician or specialist can also help identify the most appropriate trial based on your medical history and current treatment status.
Top Sponsors
University of Nebraska 1 trial
Brown University 1 trial

Recruiting Clinical Trials

NCT06480786
Recruiting
SCS for Patient With Painful Diabetic Neuropathy and Peripheral Arterial Disease
Enrollment
15 pts
Location
United States
Sponsor
University of Nebraska
View Trial →
NCT05754190
Recruiting
Assessing Symptom and Mood Dynamics in Pain Using the Smartphone Application SOMA
Enrollment
800 pts
Location
United States
Sponsor
Brown University
View Trial →

Related Conditions

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ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer  ·  Last Reviewed: April 2026  ·  Data Methodology